(2R,3R)-6,6-dimethyl-2-nitro-3-(p-tolyl)-2,3,6,7-tetrahydrobenzofuran-4(5H)-one

Base Information

Chemical Name:(2R,3R)-6,6-dimethyl-2-nitro-3-(p-tolyl)-2,3,6,7-tetrahydrobenzofuran-4(5H)-one
CAS No.:1258517-39-3
Molecular Formula:C₁₇H₁₉NO₄
Molecular Weight:301.342
Hs Code.:

Synonyms:(2R,3R)-6,6-dimethyl-2-nitro-3-(p-tolyl)-2,3,6,7-tetrahydrobenzofuran-4(5H)-one

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Chemical Property of (2R,3R)-6,6-dimethyl-2-nitro-3-(p-tolyl)-2,3,6,7-tetrahydrobenzofuran-4(5H)-one

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Technology Process of (2R,3R)-6,6-dimethyl-2-nitro-3-(p-tolyl)-2,3,6,7-tetrahydrobenzofuran-4(5H)-one

There total 3 articles about (2R,3R)-6,6-dimethyl-2-nitro-3-(p-tolyl)-2,3,6,7-tetrahydrobenzofuran-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 7559-36-6,5153-68-4
4-methyl-β-nitrostyrene

: 126-81-8
dimedone

: 1258517-39-3
(2R,3R)-6,6-dimethyl-2-nitro-3-(p-tolyl)-2,3,6,7-tetrahydrobenzofuran-4(5H)-one

Guidance literature:: 4-methyl-β-nitrostyrene; dimedone; With C₃₃H₃₀F₆N₄O₃; In dichloromethane; at 20 ℃; for 3h;

With iodine; potassium carbonate; In tetrahydrofuran; at 20 ℃; for 1h; stereoselective reaction;
DOI:10.1002/ejoc.201800575

Reference yield: 78.0%

: C₁₇H₂₁NO₄

: 1258517-39-3
(2R,3R)-6,6-dimethyl-2-nitro-3-(p-tolyl)-2,3,6,7-tetrahydrobenzofuran-4(5H)-one

Guidance literature:: With iodine; potassium carbonate; In ethyl acetate; at 25 ℃; for 2h; stereoselective reaction;

Reference yield:

: 1255534-24-7
β-bromo-4-methyl-β-nitrostyrene

: 126-81-8
dimedone

: (2S,3S)-6,6-dimethyl-2-nitro-3-(p-tolyl)-2,3,6,7-tetrahydrobenzofuran-4(5H)-one

: 1258517-39-3
(2R,3R)-6,6-dimethyl-2-nitro-3-(p-tolyl)-2,3,6,7-tetrahydrobenzofuran-4(5H)-one

Guidance literature:: With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methyl)thiourea; N,N,N,N,-tetramethylethylenediamine; In chloroform; at -20 ℃; for 48h; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ol102499r