(R)-N-(3,5-dimethyl-4-methoxyphenyl)-(1-(4-chlorophenyl)ethyl)amine

Base Information

• Chemical Name: (R)-N-(3,5-dimethyl-4-methoxyphenyl)-(1-(4-chlorophenyl)ethyl)amine
• CAS No.: 948018-43-7
• Molecular Formula: C₁₇H₂₀ClNO
• Molecular Weight: 289.805
• Mol file: 948018-43-7.mol

Synonyms:(R)-N-(3,5-dimethyl-4-methoxyphenyl)-(1-(4-chlorophenyl)ethyl)amine

Chemical Property of (R)-N-(3,5-dimethyl-4-methoxyphenyl)-(1-(4-chlorophenyl)ethyl)amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-(3,5-dimethyl-4-methoxyphenyl)-(1-(4-chlorophenyl)ethyl)amine

There total 3 articles about (R)-N-(3,5-dimethyl-4-methoxyphenyl)-(1-(4-chlorophenyl)ethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3,5-dimethyl-4-methoxyphenyl)-1-(4-chlorophenyl)ethylideneamine (948018-29-9) → (R)-N-(3,5-dimethyl-4-methoxyphenyl)-(1-(4-chlorophenyl)ethyl)amine (948018-43-7) + (S)-N-(3,5-dimethyl-4-methoxyphenyl)-(1-(4-chlorophenyl)ethyl)amine

Guidance literature:

With hydrogen; (R_Fc)-1-Ph₂P-2-((S)-MeO(2-Py)CH)ferrocene iridium complex; In methanol; toluene; at 25 ℃; for 4h; under 7500.75 Torr; Title compound not separated from byproducts.;

DOI:10.1021/ol071168t

Reference yield:

2,6-dimethyl-4-nitroanisole (14804-39-8) → (R)-N-(3,5-dimethyl-4-methoxyphenyl)-(1-(4-chlorophenyl)ethyl)amine (948018-43-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / FeCl₃*6H₂O; NH₂NH₂*H₂O; charcoal / methanol / Heating

2: 75 percent / molecular sieves 4 Angstroem / toluene / Heating

3: hydrogen / (R_Fc)-1-Ph₂P-2-((S)-MeO(2-Py)CH)ferrocene iridium complex / toluene; methanol / 4 h / 25 °C / 7500.75 Torr

With 4 A molecular sieve; hydrogen; iron(III) chloride; pyrographite; hydrazine hydrate; (R_Fc)-1-Ph₂P-2-((S)-MeO(2-Py)CH)ferrocene iridium complex; In methanol; toluene;

DOI:10.1021/ol071168t

Reference yield:

4-amino-2,6-dimethylanisole (39785-37-0) → (R)-N-(3,5-dimethyl-4-methoxyphenyl)-(1-(4-chlorophenyl)ethyl)amine (948018-43-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / molecular sieves 4 Angstroem / toluene / Heating

2: hydrogen / (R_Fc)-1-Ph₂P-2-((S)-MeO(2-Py)CH)ferrocene iridium complex / toluene; methanol / 4 h / 25 °C / 7500.75 Torr

With 4 A molecular sieve; hydrogen; (R_Fc)-1-Ph₂P-2-((S)-MeO(2-Py)CH)ferrocene iridium complex; In methanol; toluene;

DOI:10.1021/ol071168t

upstream raw materials:

N-(3,5-dimethyl-4-methoxyphenyl)-1-(4-chlorophenyl)ethylideneamine

2,6-dimethyl-4-nitroanisole

4-amino-2,6-dimethylanisole

Downstream raw materials:

(R)-1-(4-chlorophenyl)ethylamine