2-(2,3-dihydro-5-methoxy-2-oxo-3-phenylbenzofuran-3-yl)acetic acid

Base Information

• Chemical Name: 2-(2,3-dihydro-5-methoxy-2-oxo-3-phenylbenzofuran-3-yl)acetic acid
• CAS No.: 118709-27-6
• Molecular Formula: C₁₇H₁₄O₅
• Molecular Weight: 298.295
• Mol file: 118709-27-6.mol

Synonyms:2-(2,3-dihydro-5-methoxy-2-oxo-3-phenylbenzofuran-3-yl)acetic acid

Chemical Property of 2-(2,3-dihydro-5-methoxy-2-oxo-3-phenylbenzofuran-3-yl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,3-dihydro-5-methoxy-2-oxo-3-phenylbenzofuran-3-yl)acetic acid

There total 5 articles about 2-(2,3-dihydro-5-methoxy-2-oxo-3-phenylbenzofuran-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

→ 2-(2,3-dihydro-5-methoxy-2-oxo-3-phenylbenzofuran-3-yl)acetic acid (118709-27-6)

Guidance literature:

Reference yield: 75.0%

tert-butyl 2-(2,3-dihydro-5-methoxy-2-oxo-3-phenylbenzofuran-3-yl)acetate → 2-(2,3-dihydro-5-methoxy-2-oxo-3-phenylbenzofuran-3-yl)acetic acid (118709-27-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; water; at 0 ℃; for 3h; Inert atmosphere;

DOI:10.1080/00397911.2016.1226341

Reference yield:

MANDELIC ACID (611-71-2,611-72-3,17199-29-0,90-64-2) → 2-(2,3-dihydro-5-methoxy-2-oxo-3-phenylbenzofuran-3-yl)acetic acid (118709-27-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: antimony(III) chloride / neat (no solvent) / 140 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2.2: 2 h / 0 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane; water / 3 h / 0 °C / Inert atmosphere

With potassium tert-butylate; antimony(III) chloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;

DOI:10.1080/00397911.2016.1226341

upstream raw materials:

MANDELIC ACID

5-methoxy-3-phenylbenzofuran-2(3H)-one

4-methoxy-phenol