5,5-dimethyl-3-(4-{[3-(methyloxy)phenyl]oxy}phenyl)-2,4-imidazolidinedione

Base Information

• Chemical Name: 5,5-dimethyl-3-(4-{[3-(methyloxy)phenyl]oxy}phenyl)-2,4-imidazolidinedione
• CAS No.: 1311136-91-0
• Molecular Formula: C₁₈H₁₈N₂O₄
• Molecular Weight: 326.352
• Mol file: 1311136-91-0.mol

Synonyms:5,5-dimethyl-3-(4-{[3-(methyloxy)phenyl]oxy}phenyl)-2,4-imidazolidinedione

Chemical Property of 5,5-dimethyl-3-(4-{[3-(methyloxy)phenyl]oxy}phenyl)-2,4-imidazolidinedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,5-dimethyl-3-(4-{[3-(methyloxy)phenyl]oxy}phenyl)-2,4-imidazolidinedione

There total 4 articles about 5,5-dimethyl-3-(4-{[3-(methyloxy)phenyl]oxy}phenyl)-2,4-imidazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(trichloromethyl) carbonate (32315-10-9) + 2-methyl-N'-(4-{[3-(methyloxy)phenyl]oxy}phenyl)alaninamide (1311138-30-3) → 5,5-dimethyl-3-(4-{[3-(methyloxy)phenyl]oxy}phenyl)-2,4-imidazolidinedione (1311136-91-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 4-(3-methoxyphenoxy)aniline (56705-86-3) + 2-Aminoisobutyric acid (62-57-7) → 5,5-dimethyl-3-(4-{[3-(methyloxy)phenyl]oxy}phenyl)-2,4-imidazolidinedione (1311136-91-0)

Guidance literature:

2-Aminoisobutyric acid; With N-methyl-2,2,2-trifluoroacetamide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 40 - 50 ℃; for 4.5h;

di-tert-butyl dicarbonate; 4-(3-methoxyphenoxy)aniline; With dmap; In dichloromethane; at 20 ℃; Cooling with ice;

With hydrogenchloride; In dichloromethane; water; at 100 ℃; for 2h;

Reference yield:

1,1-dimethylethyl {1,1-dimethyl-2-[(4-{[3-(methyloxy)phenyl]oxy}phenyl)amino]-2-oxoethyl}carbamate (1311138-29-0) → 5,5-dimethyl-3-(4-{[3-(methyloxy)phenyl]oxy}phenyl)-2,4-imidazolidinedione (1311136-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C

2: triethylamine / dichloromethane / 0.5 h / 0 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;

upstream raw materials:

di-tert-butyl dicarbonate

4-(3-methoxyphenoxy)aniline

2-Aminoisobutyric acid

bis(trichloromethyl) carbonate