(S)-4-isopropyl-3-[(R)-4-methyl-2(-2-nitroethyl)pentanoyl]-5,5-diphenyloxazolidin-2-one

Base Information

Chemical Name:(S)-4-isopropyl-3-[(R)-4-methyl-2(-2-nitroethyl)pentanoyl]-5,5-diphenyloxazolidin-2-one
CAS No.:259857-37-9
Molecular Formula:C₂₆H₃₂N₂O₅
Molecular Weight:452.55
Hs Code.:

Synonyms:(S)-4-isopropyl-3-[(R)-4-methyl-2(-2-nitroethyl)pentanoyl]-5,5-diphenyloxazolidin-2-one

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Chemical Property of (S)-4-isopropyl-3-[(R)-4-methyl-2(-2-nitroethyl)pentanoyl]-5,5-diphenyloxazolidin-2-one

Chemical Property:

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Technology Process of (S)-4-isopropyl-3-[(R)-4-methyl-2(-2-nitroethyl)pentanoyl]-5,5-diphenyloxazolidin-2-one

There total 1 articles about (S)-4-isopropyl-3-[(R)-4-methyl-2(-2-nitroethyl)pentanoyl]-5,5-diphenyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 3638-64-0,26618-70-2
1-nitroethylene

: 218800-88-5
(S)-4-(1-methylethyl)-3-(4-methyl-1-oxopentyl)-5,5-diphenyloxazolidin-2-one

: (S)-4-isopropyl-3-[(S)-4-methyl-2(-2-nitroethyl)pentanoyl]-5,5-diphenyloxazolidin-2-one

: 259857-37-9
(S)-4-isopropyl-3-[(R)-4-methyl-2(-2-nitroethyl)pentanoyl]-5,5-diphenyloxazolidin-2-one

Guidance literature:: With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -75 ℃; for 7h;
DOI:10.1002/(SICI)1522-2675(19991215)82:12<2365::AID-HLCA2365>3.0.CO;2-#

Reference yield:

: 259857-37-9
(S)-4-isopropyl-3-[(R)-4-methyl-2(-2-nitroethyl)pentanoyl]-5,5-diphenyloxazolidin-2-one

: 259857-59-5
benzyl (R)-2-{2-[(tert-butoxycarbonyl)amino]ethyl}-3-methylpentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 88 percent / H₂ / Raney-nickel / ethanol; ethyl acetate / 16 h / 20 °C / 750.06 Torr

2.1: 87 percent / DMAP / CH₂Cl₂ / 3 h / 20 °C

3.1: LiOH; H₂O / tetrahydrofuran / 2 h

3.2: TosOH*H₂O / benzene / 10 h / Heating

4.1: 0.480 g / 4-methylmorpholine / CH₂Cl₂ / 4 h / 20 °C

With 4-methyl-morpholine; dmap; lithium hydroxide; water; hydrogen; nickel; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; 1.1: Reduction / 2.1: Substitution / 3.1: Hydrolysis / 3.2: Esterification / 4.1: Condensation;
DOI:10.1002/(SICI)1522-2675(19991215)82:12<2365::AID-HLCA2365>3.0.CO;2-#

Reference yield:

: 259857-37-9
(S)-4-isopropyl-3-[(R)-4-methyl-2(-2-nitroethyl)pentanoyl]-5,5-diphenyloxazolidin-2-one

: (R)-2-(2-Amino-ethyl)-4-methyl-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 88 percent / H₂ / Raney-nickel / ethanol; ethyl acetate / 16 h / 20 °C / 750.06 Torr

2.1: 87 percent / DMAP / CH₂Cl₂ / 3 h / 20 °C

3.1: LiOH; H₂O / tetrahydrofuran / 2 h

3.2: TosOH*H₂O / benzene / 10 h / Heating

With dmap; lithium hydroxide; water; hydrogen; nickel; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; 1.1: Reduction / 2.1: Substitution / 3.1: Hydrolysis / 3.2: Esterification;
DOI:10.1002/(SICI)1522-2675(19991215)82:12<2365::AID-HLCA2365>3.0.CO;2-#