4-bromo-N-[3-(chloromethyl)-8-methyl-7-quinolinyl]benzamide hydrochloride

Base Information

Chemical Name:4-bromo-N-[3-(chloromethyl)-8-methyl-7-quinolinyl]benzamide hydrochloride
CAS No.:521074-38-4
Molecular Formula:C₁₈H₁₄BrClN₂O*ClH
Molecular Weight:426.14
Hs Code.:

Synonyms:4-bromo-N-[3-(chloromethyl)-8-methyl-7-quinolinyl]benzamide hydrochloride

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Chemical Property of 4-bromo-N-[3-(chloromethyl)-8-methyl-7-quinolinyl]benzamide hydrochloride

Chemical Property:

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Technology Process of 4-bromo-N-[3-(chloromethyl)-8-methyl-7-quinolinyl]benzamide hydrochloride

There total 4 articles about 4-bromo-N-[3-(chloromethyl)-8-methyl-7-quinolinyl]benzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 521074-36-2
4-bromo-N-(3-formyl-8-methyl-7-quinolinyl)benzamide

: 521074-38-4
4-bromo-N-[3-(chloromethyl)-8-methyl-7-quinolinyl]benzamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 2 h / 20 °C

2: potassium carbonate / acetonitrile / 2 h / 80 °C

3: hydrogenchloride / 1 h / 100 °C

4: dmap; ethylene dichloride hydrochloride; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Cooling with ice

With hydrogenchloride; dmap; thionyl chloride; ethylene dichloride hydrochloride; potassium carbonate; triethylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm201596h

Reference yield:

: 349143-07-3
4-bromo-N-(2-methyl-3-nitrophenyl)benzamide

: 521074-38-4
4-bromo-N-[3-(chloromethyl)-8-methyl-7-quinolinyl]benzamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: iron; calcium chloride / ethanol; water / 4 h / Reflux

2.1: ethanol / 24 h / Reflux

2.2: 4 h / 20 °C

3.1: sodium tetrahydroborate / ethanol / 3 h / 20 °C / Cooling with ice

4.1: thionyl chloride / 2 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; iron; calcium chloride; In ethanol; water;
DOI:10.1021/jm201596h

Reference yield:

: 521074-35-1
N-(3-amino-2-methylphenyl)-4-bromobenzamide

: 521074-38-4
4-bromo-N-[3-(chloromethyl)-8-methyl-7-quinolinyl]benzamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 24 h / Reflux

1.2: 4 h / 20 °C

2.1: sodium tetrahydroborate / ethanol / 3 h / 20 °C / Cooling with ice

3.1: thionyl chloride / 2 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; In ethanol;
DOI:10.1021/jm201596h