benzyl {1-[4-({[1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)-3-fluorophenyl]-1H-imidazol-2-yl}methyl(methyl)carbamate

Base Information

Chemical Name:benzyl {1-[4-({[1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)-3-fluorophenyl]-1H-imidazol-2-yl}methyl(methyl)carbamate
CAS No.:540510-45-0
Molecular Formula:C₃₁H₂₂F₅N₇O₃
Molecular Weight:635.553
Hs Code.:

benzyl {1-[4-({[1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)-3-fluorophenyl]-1H-imidazol-2-yl}methyl(methyl)carbamate

Synonyms:benzyl {1-[4-({[1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)-3-fluorophenyl]-1H-imidazol-2-yl}methyl(methyl)carbamate

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Chemical Property of benzyl {1-[4-({[1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)-3-fluorophenyl]-1H-imidazol-2-yl}methyl(methyl)carbamate

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Technology Process of benzyl {1-[4-({[1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)-3-fluorophenyl]-1H-imidazol-2-yl}methyl(methyl)carbamate

There total 10 articles about benzyl {1-[4-({[1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)-3-fluorophenyl]-1H-imidazol-2-yl}methyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 473927-49-0
benzyl 1H-imidazol-2-yl-methyl-(methyl)carbamate

: 66-71-7
1,10-Phenanthroline

aqueous NH₄OH: aqueous NH₄OH

: 29632-74-4
2-fluro-4-iodoaniline

: 540510-45-0
benzyl {1-[4-({[1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)-3-fluorophenyl]-1H-imidazol-2-yl}methyl(methyl)carbamate

Guidance literature:: With CuI; potassium carbonate; In hexane; dimethyl sulfoxide; ethyl acetate;

Reference yield: 52.0%

: 754193-45-8
2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl chloride

: 540510-44-9
[1-(4-amino-3-fluorophenyl)-1H-imidazol-2-ylmethyl]methylcarbamic acid benzyl ester

: 540510-45-0
benzyl {1-[4-({[1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)-3-fluorophenyl]-1H-imidazol-2-yl}methyl(methyl)carbamate

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/jm0497949

Reference yield:

: 473927-72-9
1-(1H-imidazol-2-yl)-N-methylmethanamine

: 540510-45-0
benzyl {1-[4-({[1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)-3-fluorophenyl]-1H-imidazol-2-yl}methyl(methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Et₃N / CH₂Cl₂; tetrahydrofuran / 1 h / 20 °C

1.2: TFA / ethyl acetate / 0.5 h / Heating

2.1: 67 percent / K₂CO₃; CuI / dimethylsulfoxide / 12 h / 120 °C

3.1: 52 percent / (dimethylamino)pyridine / CH₂Cl₂ / 12 h / 20 °C

With dmap; copper(l) iodide; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 2.1: Ullmann coupling;
DOI:10.1021/jm0497949