[(1R,2R)-2-(Benzyl-hydroxy-amino)-1-(tert-butyl-diphenyl-silanyloxymethyl)-4-trimethylsilanyl-but-3-ynyl]-carbamic acid tert-butyl ester

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Chemical Name:[(1R,2R)-2-(Benzyl-hydroxy-amino)-1-(tert-butyl-diphenyl-silanyloxymethyl)-4-trimethylsilanyl-but-3-ynyl]-carbamic acid tert-butyl ester
CAS No.:212330-31-9
Molecular Formula:C₃₆H₅₀N₂O₄Si₂
Molecular Weight:630.975
Hs Code.:

Synonyms:[(1R,2R)-2-(Benzyl-hydroxy-amino)-1-(tert-butyl-diphenyl-silanyloxymethyl)-4-trimethylsilanyl-but-3-ynyl]-carbamic acid tert-butyl ester

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Chemical Property of [(1R,2R)-2-(Benzyl-hydroxy-amino)-1-(tert-butyl-diphenyl-silanyloxymethyl)-4-trimethylsilanyl-but-3-ynyl]-carbamic acid tert-butyl ester

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Technology Process of [(1R,2R)-2-(Benzyl-hydroxy-amino)-1-(tert-butyl-diphenyl-silanyloxymethyl)-4-trimethylsilanyl-but-3-ynyl]-carbamic acid tert-butyl ester

There total 1 articles about [(1R,2R)-2-(Benzyl-hydroxy-amino)-1-(tert-butyl-diphenyl-silanyloxymethyl)-4-trimethylsilanyl-but-3-ynyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 54655-07-1
lithium trimethylsilylacetylenide

: 158723-49-0,188965-46-0
(Z)-N-[(2R)-2-(tert-butoxycarbonylamino)-3-(tertbutyldiphenylsilyloxy)-propylidene]benzylamine N-oxide

: 212330-31-9
[(1R,2R)-2-(Benzyl-hydroxy-amino)-1-(tert-butyl-diphenyl-silanyloxymethyl)-4-trimethylsilanyl-but-3-ynyl]-carbamic acid tert-butyl ester

Guidance literature:: In tetrahydrofuran; at -80 ℃; for 0.25h;
DOI:10.1021/jo9714775

Reference yield: 70.0%

: 212330-31-9
[(1R,2R)-2-(Benzyl-hydroxy-amino)-1-(tert-butyl-diphenyl-silanyloxymethyl)-4-trimethylsilanyl-but-3-ynyl]-carbamic acid tert-butyl ester

: 212330-32-0
[(1R,2R)-2-(Benzyl-hydroxy-amino)-1-hydroxymethyl-but-3-ynyl]-carbamic acid tert-butyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1021/jo9714775

Reference yield:

: 212330-31-9
[(1R,2R)-2-(Benzyl-hydroxy-amino)-1-(tert-butyl-diphenyl-silanyloxymethyl)-4-trimethylsilanyl-but-3-ynyl]-carbamic acid tert-butyl ester

: 212330-33-1
(3R,4R)-5-acetoxy-3-(N-acetoxy-N-benzylamino)-4-[(tert-butoxycarbonyl)amino]-1-pentyne

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / Bu₄NF / tetrahydrofuran / 1 h / Ambient temperature

2: 100 percent / pyridine / CH₂Cl₂ / 1 h / Ambient temperature

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9714775