2-(3,4-dimethoxyphenyl)-2-isopropyl-5-methylamino>valeronitrile

Base Information

Chemical Name:2-(3,4-dimethoxyphenyl)-2-isopropyl-5-methylamino>valeronitrile
CAS No.:124562-83-0
Molecular Formula:C₂₆H₃₇N₃O₂
Molecular Weight:423.599
Hs Code.:

2-(3,4-dimethoxyphenyl)-2-isopropyl-5-<N-<4-(methylamino)phenethyl>methylamino>valeronitrile

Synonyms:2-(3,4-dimethoxyphenyl)-2-isopropyl-5-methylamino>valeronitrile

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Chemical Property of 2-(3,4-dimethoxyphenyl)-2-isopropyl-5-methylamino>valeronitrile

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Technology Process of 2-(3,4-dimethoxyphenyl)-2-isopropyl-5-methylamino>valeronitrile

There total 4 articles about 2-(3,4-dimethoxyphenyl)-2-isopropyl-5-methylamino>valeronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: N-[4-(2-{[4-Cyano-4-(3,4-dimethoxy-phenyl)-5-methyl-hexyl]-methyl-amino}-ethyl)-phenyl]-formamide

: 124562-83-0
2-(3,4-dimethoxyphenyl)-2-isopropyl-5-methylamino>valeronitrile

Guidance literature:: With borane; In tetrahydrofuran; 1.) room temp., 18 h, 2.) 60 deg C, 2 h;
DOI:10.1021/jm00164a064

Reference yield:

: 24954-63-0
2,2,2-Trifluoro-N-(2-(4-nitrophenyl)ethyl)acetamide

: 124562-83-0
2-(3,4-dimethoxyphenyl)-2-isopropyl-5-methylamino>valeronitrile

Guidance literature:: Multi-step reaction with 6 steps

1: NaH / tetrahydrofuran / 2 h / Ambient temperature

2: 70 percent / aq. 5 N NaOH / methanol / 0.5 h / Ambient temperature

3: 76 percent / Et₃N / 1,2-dimethoxy-ethane / 16 h / Heating

4: 83 percent / H₂, aq. 37percent HCl / 10percent Pd/C / tetrahydrofuran / 24 h / 2585.7 Torr / Ambient temperature

5: 606 mg / 24 h / 55 °C

6: 70 percent / BH₃ / tetrahydrofuran / 1.) room temp., 18 h, 2.) 60 deg C, 2 h

With hydrogenchloride; sodium hydroxide; borane; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane;
DOI:10.1021/jm00164a064

Reference yield:

: 124562-86-3
2-(3,4-dimethoxyphenyl)-2-isopropyl-5-valeronitrile

: 124562-83-0
2-(3,4-dimethoxyphenyl)-2-isopropyl-5-methylamino>valeronitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / H₂, aq. 37percent HCl / 10percent Pd/C / tetrahydrofuran / 24 h / 2585.7 Torr / Ambient temperature

2: 606 mg / 24 h / 55 °C

3: 70 percent / BH₃ / tetrahydrofuran / 1.) room temp., 18 h, 2.) 60 deg C, 2 h

With hydrogenchloride; borane; hydrogen; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1021/jm00164a064