6-phenoxy-2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one

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Chemical Name:6-phenoxy-2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one
CAS No.:1234349-56-4
Molecular Formula:C₃₀H₂₉N₇O₂
Molecular Weight:519.606
Hs Code.:

Synonyms:6-phenoxy-2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one

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Chemical Property of 6-phenoxy-2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one

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Technology Process of 6-phenoxy-2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one

There total 5 articles about 6-phenoxy-2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000802-52-7
1-[2-(pyrrolidin-1-yl)ethyl]-4-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1234349-81-5
2-[3-(5-bromopyrimidin-2-yl)benzyl]-6-phenoxy-2H-pyridazin-3-one

: 1234349-56-4
6-phenoxy-2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one

Guidance literature:: With potassium phosphate tribasic trihydrate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; at 85 ℃; for 42h; Inert atmosphere;

Reference yield:

: 87199-15-3
[3-(hydroxymethyl)phenyl]boronic acid

: 1234349-56-4
6-phenoxy-2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 18 h / 80 °C / Inert atmosphere

2: thionyl chloride / 18 h / 20 - 30 °C

3: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

4: triethylamine; potassium phosphate tribasic trihydrate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; 1,2-dimethoxyethane / 42 h / 85 °C / Inert atmosphere

With thionyl chloride; potassium phosphate tribasic trihydrate; sodium carbonate; caesium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1092568-90-5
(3-(5-bromopyrimidin-2-yl)phenyl)methanol

: 1234349-56-4
6-phenoxy-2-(3-{5-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-pyrimidin-2-yl}benzyl)-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 18 h / 20 - 30 °C

2: caesium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

3: triethylamine; potassium phosphate tribasic trihydrate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; 1,2-dimethoxyethane / 42 h / 85 °C / Inert atmosphere

With thionyl chloride; potassium phosphate tribasic trihydrate; caesium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;