(2R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-pyridin-2-yl]-2-methyl-3,4-dihydro-2H-pyrrole-2-carboxamide

Base Information

Chemical Name:(2R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-pyridin-2-yl]-2-methyl-3,4-dihydro-2H-pyrrole-2-carboxamide
CAS No.:1195787-96-2
Molecular Formula:C₃₁H₂₉F₇N₄O₂
Molecular Weight:622.586
Hs Code.:

(2R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-pyridin-2-yl]-2-methyl-3,4-dihydro-2H-pyrrole-2-carboxamide

Synonyms:(2R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-pyridin-2-yl]-2-methyl-3,4-dihydro-2H-pyrrole-2-carboxamide

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Chemical Property of (2R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-pyridin-2-yl]-2-methyl-3,4-dihydro-2H-pyrrole-2-carboxamide

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Technology Process of (2R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-pyridin-2-yl]-2-methyl-3,4-dihydro-2H-pyrrole-2-carboxamide

There total 6 articles about (2R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-pyridin-2-yl]-2-methyl-3,4-dihydro-2H-pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1195787-95-1
methyl (2R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-pyridin-2-yl]-2-methyl-3,4-dihydro-2H-pyrrole-2-carboxylate

: 1195787-96-2
(2R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-pyridin-2-yl]-2-methyl-3,4-dihydro-2H-pyrrole-2-carboxamide

Guidance literature:: With ammonia; In methanol; at 0 - 40 ℃;

Reference yield:

: 403519-98-2
(2R)-2-amino-2-methylpent-4-ynoic acid

: 1195787-96-2
(2R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-pyridin-2-yl]-2-methyl-3,4-dihydro-2H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 17.5 h / 2 - 40 °C

2.1: potassium carbonate / 1,4-dioxane; water / 0.5 h / 20 °C

2.2: 17 h / 40 °C / Inert atmosphere

3.1: copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine / bis-triphenylphosphine-palladium(II) chloride / Reflux

3.2: Heating

4.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere; Reflux

4.2: 0.25 h

5.1: silver trifluoromethanesulfonate / dichloromethane; acetonitrile / 24 h / Reflux

6.1: ammonia / methanol / 120 h / 20 °C

With copper(l) iodide; thionyl chloride; ammonia; silver trifluoromethanesulfonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;

Reference yield:

: 81136-95-0,88820-88-6
methyl (R)-2-amino-2-methylpent-4-ynoate

: 1195787-96-2
(2R)-5-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-pyridin-2-yl]-2-methyl-3,4-dihydro-2H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / 1,4-dioxane; water / 0.5 h / 20 °C

1.2: 17 h / 40 °C / Inert atmosphere

2.1: copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine / bis-triphenylphosphine-palladium(II) chloride / Reflux

2.2: Heating

3.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere; Reflux

3.2: 0.25 h

4.1: silver trifluoromethanesulfonate / dichloromethane; acetonitrile / 24 h / Reflux

5.1: ammonia / methanol / 120 h / 20 °C

With copper(l) iodide; ammonia; silver trifluoromethanesulfonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;