2-(2-chloro-phenylamino)-7-hydroxy-6,6-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-h]isoquinolin-9-one

Base Information

Chemical Name:2-(2-chloro-phenylamino)-7-hydroxy-6,6-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-h]isoquinolin-9-one
CAS No.:1026844-32-5
Molecular Formula:C₁₈H₁₇ClN₄O₂
Molecular Weight:356.812
Hs Code.:

2-(2-chloro-phenylamino)-7-hydroxy-6,6-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-<i>h</i>]isoquinolin-9-one

Synonyms:2-(2-chloro-phenylamino)-7-hydroxy-6,6-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-h]isoquinolin-9-one

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Chemical Property of 2-(2-chloro-phenylamino)-7-hydroxy-6,6-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-h]isoquinolin-9-one

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Technology Process of 2-(2-chloro-phenylamino)-7-hydroxy-6,6-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-h]isoquinolin-9-one

There total 10 articles about 2-(2-chloro-phenylamino)-7-hydroxy-6,6-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-h]isoquinolin-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 452296-25-2
2-(2-chloro-phenylamino)-6,6-dimethyl-1,6-dihydro-imidazo[4,5-h]isoquinoline-7,9-dione

: 1026844-32-5
2-(2-chloro-phenylamino)-7-hydroxy-6,6-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-h]isoquinolin-9-one

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm020113o

Reference yield:

: 5488-36-8
4,4-dimethyl-4H-isoquinoline-1,3-dione

: 1026844-32-5
2-(2-chloro-phenylamino)-7-hydroxy-6,6-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-h]isoquinolin-9-one

Guidance literature:: Multi-step reaction with 9 steps

1: 93 percent / H₂SO₄; HNO₃ / 0 - 5 °C

2: 98 percent / H₂ / 10percent Pd/C / methanol / 1.5 h / 2585.81 Torr

3: 86 percent / 3 h / 20 °C

4: 90percent aq. HNO₃ / -20 °C

5: 99 percent / 90percent aq. H₂SO₄ / 8 h / 70 °C

6: 100 percent / H₂ / PtO₂ / methanol / 1.25 h / 2585.81 Torr

7: ethyl acetate / 20 °C

8: 93 percent / DCC / tetrahydrofuran / Heating

9: aq. NaBH₄ / tetrahydrofuran / 20 °C

With sodium tetrahydroborate; sulfuric acid; hydrogen; nitric acid; dicyclohexyl-carbodiimide; platinum(IV) oxide; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1021/jm020113o

Reference yield:

: 14576-21-7
4,4-dimethyl-7-nitro-2H-3,4-dihydro-isoquinolin-1,3-dione

: 1026844-32-5
2-(2-chloro-phenylamino)-7-hydroxy-6,6-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-h]isoquinolin-9-one

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / H₂ / 10percent Pd/C / methanol / 1.5 h / 2585.81 Torr

2: 86 percent / 3 h / 20 °C

3: 90percent aq. HNO₃ / -20 °C

4: 99 percent / 90percent aq. H₂SO₄ / 8 h / 70 °C

5: 100 percent / H₂ / PtO₂ / methanol / 1.25 h / 2585.81 Torr

6: ethyl acetate / 20 °C

7: 93 percent / DCC / tetrahydrofuran / Heating

8: aq. NaBH₄ / tetrahydrofuran / 20 °C

With sodium tetrahydroborate; hydrogen; dicyclohexyl-carbodiimide; platinum(IV) oxide; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1021/jm020113o