2-[5-chloro-1-(4-fluorophenyl)-3-1H-indolylthio]acetic acid

Base Information

• Chemical Name: 2-[5-chloro-1-(4-fluorophenyl)-3-1H-indolylthio]acetic acid
• CAS No.: 170232-27-6
• Molecular Formula: C₁₆H₁₁ClFNO₂S
• Molecular Weight: 335.786
• Mol file: 170232-27-6.mol

Synonyms:2-[5-chloro-1-(4-fluorophenyl)-3-1H-indolylthio]acetic acid

Chemical Property of 2-[5-chloro-1-(4-fluorophenyl)-3-1H-indolylthio]acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-[5-chloro-1-(4-fluorophenyl)-3-1H-indolylthio]acetic acid

There total 2 articles about 2-[5-chloro-1-(4-fluorophenyl)-3-1H-indolylthio]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

mercaptoacetic acid (68-11-1) + 5-chloro-2,3-dihydro-1-(4-fluorophenyl)-1H-indol-3-one (170232-17-4) → 2-[5-chloro-1-(4-fluorophenyl)-3-1H-indolylthio]acetic acid (170232-27-6)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 18h; Heating;

DOI:10.1021/jm960159f

Reference yield:

3-acetoxy-5-chloro-1-(4-fluorophenyl)-1H-indole (170232-37-8) → 2-[5-chloro-1-(4-fluorophenyl)-3-1H-indolylthio]acetic acid (170232-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / Na₂SO₃*7H₂O / H₂O; ethanol / 1.) reflux, 1 h, 2.) RT, 18 h

2: p-toluenesulfonic acid / toluene / 18 h / Heating

With toluene-4-sulfonic acid; sodium sulfite; In ethanol; water; toluene;

DOI:10.1021/jm960159f

Reference yield:

2-[5-chloro-1-(4-fluorophenyl)-3-1H-indolylthio]acetic acid (170232-27-6) → 2-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-ylsulfanyl]ethanol (170232-28-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h; Yield given; Heating;

DOI:10.1021/jm960159f

upstream raw materials:

mercaptoacetic acid

5-chloro-2,3-dihydro-1-(4-fluorophenyl)-1H-indol-3-one

3-acetoxy-5-chloro-1-(4-fluorophenyl)-1H-indole

Downstream raw materials:

2-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-ylsulfanyl]ethanol

Methanesulfonic acid 2-[5-chloro-1-(4-fluoro-phenyl)-1H-indol-3-ylsulfanyl]-ethyl ester