(+/-)-diethyl ((1-hydroxy-3-(4-fluorophenyl)-2-oxoimidazolidin-4-yl)methyl)phosphonate

Base Information

Chemical Name:(+/-)-diethyl ((1-hydroxy-3-(4-fluorophenyl)-2-oxoimidazolidin-4-yl)methyl)phosphonate
CAS No.:1642790-74-6
Molecular Formula:C₁₄H₂₀FN₂O₅P
Molecular Weight:346.295
Hs Code.:

Synonyms:(+/-)-diethyl ((1-hydroxy-3-(4-fluorophenyl)-2-oxoimidazolidin-4-yl)methyl)phosphonate

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Chemical Property of (+/-)-diethyl ((1-hydroxy-3-(4-fluorophenyl)-2-oxoimidazolidin-4-yl)methyl)phosphonate

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Technology Process of (+/-)-diethyl ((1-hydroxy-3-(4-fluorophenyl)-2-oxoimidazolidin-4-yl)methyl)phosphonate

There total 4 articles about (+/-)-diethyl ((1-hydroxy-3-(4-fluorophenyl)-2-oxoimidazolidin-4-yl)methyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1642790-71-3
(+/-)-diethyl ((1-(benzyloxy)-3-(4-fluorophenyl)-2-oxoimidazolidin-4-yl)methyl)phosphonate

: 1642790-74-6
(+/-)-diethyl ((1-hydroxy-3-(4-fluorophenyl)-2-oxoimidazolidin-4-yl)methyl)phosphonate

Guidance literature:: With 10% palladium hydroxide on charcoal; hydrogen; In ethanol; at 20 ℃; for 3h; Schlenk technique; Inert atmosphere;
DOI:10.1039/c4ra00757c

Reference yield:

: 1639809-91-8
(E)-diethyl (3-(1-(benzyloxy)-3-(4-fluorophenyl)ureido)prop-1-en-1-yl)phosphonate

: 1642790-74-6
(+/-)-diethyl ((1-hydroxy-3-(4-fluorophenyl)-2-oxoimidazolidin-4-yl)methyl)phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran / 48 h / 70 °C / Inert atmosphere

2: 10% palladium hydroxide on charcoal; hydrogen / ethanol / 3 h / 20 °C / Schlenk technique; Inert atmosphere

With 10% palladium hydroxide on charcoal; potassium tert-butylate; hydrogen; In tetrahydrofuran; ethanol;
DOI:10.1039/c4ra00757c

Reference yield:

: (E)-diethyl (3-oxoprop-1-en-1-yl)phosphonate

: 1642790-74-6
(+/-)-diethyl ((1-hydroxy-3-(4-fluorophenyl)-2-oxoimidazolidin-4-yl)methyl)phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

1.3: 2 h / Inert atmosphere

2.1: dichloromethane / 3 h / 20 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 48 h / 70 °C / Inert atmosphere

4.1: 10% palladium hydroxide on charcoal; hydrogen / ethanol / 3 h / 20 °C / Schlenk technique; Inert atmosphere

With 10% palladium hydroxide on charcoal; potassium tert-butylate; hydrogen; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1039/c4ra00757c