N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-carbamoylthieno<2,3-b>pyridine

Base Information

Chemical Name:N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-carbamoylthieno<2,3-b>pyridine
CAS No.:127019-46-9
Molecular Formula:C₁₈H₁₇N₃O₃S
Molecular Weight:355.417
Hs Code.:

Synonyms:N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-carbamoylthieno<2,3-b>pyridine

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Chemical Property of N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-carbamoylthieno<2,3-b>pyridine

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Technology Process of N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-carbamoylthieno<2,3-b>pyridine

There total 4 articles about N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-carbamoylthieno<2,3-b>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 127019-45-8
N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-cyanothieno<2,3-b>pyridine

: 127019-46-9
N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-carbamoylthieno<2,3-b>pyridine

Guidance literature:: With sodium hydroxide; dihydrogen peroxide; In methanol; ethanol; at 40 - 50 ℃; for 80h;
DOI:10.1002/jhet.5570260616

Reference yield:

: 40357-96-8
5-nitro-thiophene-3-carboxylic acid

: 127019-46-9
N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-carbamoylthieno<2,3-b>pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Sn, HCl, 2.) HCl / 1.) 40 - 45 deg C, 2.) methanol, reflux, 24 h, room temperature, 24 h

2: 15 percent / toluene / 48 h / Heating

3: 84 percent / 30percent H₂O₂, 5M NaOH / methanol; ethanol / 80 h / 40 - 50 °C

With hydrogenchloride; sodium hydroxide; tin; dihydrogen peroxide; In methanol; ethanol; toluene;
DOI:10.1002/jhet.5570260616

Reference yield:

: 88-13-1
3-Thiophene carboxylic acid

: 127019-46-9
N-3-((S)-1-hydroxymethyl-2-phenylethyl)carboxamide-5-carbamoylthieno<2,3-b>pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / HNO₃, H₂SO₄ / -10 - -5 °C

2: 1.) Sn, HCl, 2.) HCl / 1.) 40 - 45 deg C, 2.) methanol, reflux, 24 h, room temperature, 24 h

3: 15 percent / toluene / 48 h / Heating

4: 84 percent / 30percent H₂O₂, 5M NaOH / methanol; ethanol / 80 h / 40 - 50 °C

With hydrogenchloride; sodium hydroxide; tin; sulfuric acid; dihydrogen peroxide; nitric acid; In methanol; ethanol; toluene;
DOI:10.1002/jhet.5570260616