Phenylmethyl 2-hydroxy-4-(methoxymethoxy)-6-methylbenzoate

Base Information

Chemical Name:Phenylmethyl 2-hydroxy-4-(methoxymethoxy)-6-methylbenzoate
CAS No.:869996-17-8
Molecular Formula:C₁₇H₁₈O₅
Molecular Weight:302.327
Hs Code.:
DSSTox Substance ID:DTXSID001191858

Synonyms:Phenylmethyl 2-hydroxy-4-(methoxymethoxy)-6-methylbenzoate;DTXSID001191858;869996-17-8

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Phenylmethyl 2-hydroxy-4-(methoxymethoxy)-6-methylbenzoate

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:302.11542367
Heavy Atom Count:22
Complexity:340

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC(=C1C(=O)OCC2=CC=CC=C2)O)OCOC

Technology Process of Phenylmethyl 2-hydroxy-4-(methoxymethoxy)-6-methylbenzoate

There total 4 articles about Phenylmethyl 2-hydroxy-4-(methoxymethoxy)-6-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 38862-71-4
benzyl 2,4-dihydroxy-6-methylbenzoate

: 107-30-2
chloromethyl methyl ether

: 869996-17-8
benzyl 2-hydroxy-4-(methoxymethoxy)-6-methylbenzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jo051384k

Reference yield:

: 504-15-4
orcinol

: 869996-17-8
benzyl 2-hydroxy-4-(methoxymethoxy)-6-methylbenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: POCl₃ / 12 h / 20 °C

1.2: 80 percent / NaOH / H₂O / 0.17 h / pH 10 / Heating

2.1: 77 percent / NaH₂PO₄; NaClO₂ / H₂O; dimethylsulfoxide / 20 °C

3.1: 78 percent / KHCO₃ / dimethylformamide / 20 °C

4.1: 92 percent / i-Pr₂NEt / CH₂Cl₂ / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; potassium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo051384k

Reference yield:

: 487-69-4
2,4-dihydroxy-6-methylbenzaldehyde

: 869996-17-8
benzyl 2-hydroxy-4-(methoxymethoxy)-6-methylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / NaH₂PO₄; NaClO₂ / H₂O; dimethylsulfoxide / 20 °C

2: 78 percent / KHCO₃ / dimethylformamide / 20 °C

3: 92 percent / i-Pr₂NEt / CH₂Cl₂ / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; potassium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo051384k