methyl N-[(4-methoxyphenyl)sulfonyl]-S-(3-hydroxy-3(R)-phenylpropyl)-D-penicillamine

Base Information

Chemical Name:methyl N-[(4-methoxyphenyl)sulfonyl]-S-(3-hydroxy-3(R)-phenylpropyl)-D-penicillamine
CAS No.:253195-01-6
Molecular Formula:C₂₂H₂₉NO₆S₂
Molecular Weight:467.607
Hs Code.:

Synonyms:methyl N-[(4-methoxyphenyl)sulfonyl]-S-(3-hydroxy-3(R)-phenylpropyl)-D-penicillamine

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Chemical Property of methyl N-[(4-methoxyphenyl)sulfonyl]-S-(3-hydroxy-3(R)-phenylpropyl)-D-penicillamine

Chemical Property:

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Technology Process of methyl N-[(4-methoxyphenyl)sulfonyl]-S-(3-hydroxy-3(R)-phenylpropyl)-D-penicillamine

There total 3 articles about methyl N-[(4-methoxyphenyl)sulfonyl]-S-(3-hydroxy-3(R)-phenylpropyl)-D-penicillamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: (R)-2-Amino-3-((R)-3-hydroxy-3-phenyl-propylsulfanyl)-3-methyl-butyric acid methyl ester

: 253195-01-6
methyl N-[(4-methoxyphenyl)sulfonyl]-S-(3-hydroxy-3(R)-phenylpropyl)-D-penicillamine

Guidance literature:: With triethylamine; In 1,4-dioxane; water; at 20 ℃; for 18h;
DOI:10.1021/jm990330y

Reference yield:

: 34297-27-3
D-penicillamine methyl ester hydrochloride

: 253195-01-6
methyl N-[(4-methoxyphenyl)sulfonyl]-S-(3-hydroxy-3(R)-phenylpropyl)-D-penicillamine

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 20 °C

2: Et₃N / dioxane; H₂O / 18 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1: Alkylation / 2: sulfonylation;
DOI:10.1021/jm990330y

Reference yield:

: 100306-33-0,125712-82-5
(1R)-3-chloro-1-phenylpropanol

: 253195-01-6
methyl N-[(4-methoxyphenyl)sulfonyl]-S-(3-hydroxy-3(R)-phenylpropyl)-D-penicillamine

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 20 °C

2: Et₃N / dioxane; H₂O / 18 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1: Alkylation / 2: sulfonylation;
DOI:10.1021/jm990330y