(3R,4R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-3,4-dimethyl-dihydro-furan-2-one

Base Information

Chemical Name:(3R,4R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-3,4-dimethyl-dihydro-furan-2-one
CAS No.:106820-57-9
Molecular Formula:C₂₃H₃₀O₅Si
Molecular Weight:414.574
Hs Code.:

Synonyms:(3R,4R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-3,4-dimethyl-dihydro-furan-2-one

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Chemical Property of (3R,4R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-3,4-dimethyl-dihydro-furan-2-one

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Technology Process of (3R,4R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-3,4-dimethyl-dihydro-furan-2-one

There total 4 articles about (3R,4R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-3,4-dimethyl-dihydro-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 106820-56-8
(S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3,4-dimethyl-5H-furan-2-one

: 106820-57-9
(3R,4R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-3,4-dimethyl-dihydro-furan-2-one

Guidance literature:: With osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; In tetrahydrofuran; tert-butyl alcohol; for 96h; Ambient temperature;
DOI:10.1021/jo00382a043

Reference yield:

: 99315-76-1
(5S)-5-(tert-butyldiphenylsiloxymethyl)-2(5H)-furanone

: 106820-57-9
(3R,4R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-3,4-dimethyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / diethyl ether / 24 h / Ambient temperature

2: 1.) LiHMDS / 1.) THF, -78 deg C, 0.5 h, 2.) THF, -78 deg C to -40 deg C, 0.5 h

3: 84 percent / CaCO₃ / toluene / 2 h / Heating

4: 72 percent / 4-methylmorpholine N-oxide, OsO₄, H₂O / tetrahydrofuran; 2-methyl-propan-2-ol / 96 h / Ambient temperature

With osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; calcium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; toluene; tert-butyl alcohol;
DOI:10.1021/jo00382a043

Reference yield:

: 106820-55-7
(3aS,4S,6aR)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-6a-methyl-3,3a,4,6a-tetrahydro-furo[3,4-c]pyrazol-6-one

: 106820-57-9
(3R,4R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3,4-dihydroxy-3,4-dimethyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / CaCO₃ / toluene / 2 h / Heating

2: 72 percent / 4-methylmorpholine N-oxide, OsO₄, H₂O / tetrahydrofuran; 2-methyl-propan-2-ol / 96 h / Ambient temperature

With osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; calcium carbonate; In tetrahydrofuran; toluene; tert-butyl alcohol;
DOI:10.1021/jo00382a043