4-(4-Chlorophenyl)cyclohexanecarbohydrazide

Base Information

• Chemical Name: 4-(4-Chlorophenyl)cyclohexanecarbohydrazide
• CAS No.: 368870-04-6
• Molecular Formula: C₁₃H₁₇ClN₂O
• Molecular Weight: 252.744
• DSSTox Substance ID: DTXSID00381543
• Mol file: 368870-04-6.mol

Synonyms:4-(4-chlorophenyl)cyclohexanecarbohydrazide;368870-04-6;4-(4-chlorophenyl)cyclohexane-1-carbohydrazide;Maybridge4_002727;DTXSID00381543;HMS1528L21;CCG-251659;IDI1_032605;FT-0616613;SR-01000003833;SR-01000003833-1;BRD-K33132133-001-01-5

Chemical Property of 4-(4-Chlorophenyl)cyclohexanecarbohydrazide

Chemical Property:

• Vapor Pressure: 4.44E-08mmHg at 25°C
• Melting Point: 208℃
• Boiling Point: 444°Cat760mmHg
• Flash Point: 222.3°C
• PSA: 55.12000
• Density: 1.204g/cm³
• LogP: 3.69490
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 252.1029409
• Heavy Atom Count: 17
• Complexity: 256

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(CCC1C2=CC=C(C=C2)Cl)C(=O)NN

Technology Process of 4-(4-Chlorophenyl)cyclohexanecarbohydrazide

There total 2 articles about 4-(4-Chlorophenyl)cyclohexanecarbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl trans-4-(4-chlorophenyl)cyclohexane-1-carboxylate (128208-09-3) → 4-(4-chlorophenyl)cyclohexanecarbohydrazide (368870-04-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.14233/ajchem.2015.18731

Reference yield:

trans-4-(p-chlorophenyl)cyclohexane carboxylic acid (95233-37-7,1346600-43-8) → 4-(4-chlorophenyl)cyclohexanecarbohydrazide (368870-04-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 10 h / Reflux

2: hydrazine hydrate / ethanol / 3 h / Reflux

With sulfuric acid; hydrazine hydrate; In ethanol;

DOI:10.14233/ajchem.2015.18731

upstream raw materials:

trans-4-(p-chlorophenyl)cyclohexane carboxylic acid

methyl trans-4-(4-chlorophenyl)cyclohexane-1-carboxylate

Refernces

• 1、 Venkatasatyanarayana,Lakshmana Rao,Thirumala Chary,Ram,Balram,Laxminarayana. "Synthesis and biological evaluation of 4-(4-chlorophenyl)cyclohexane carbohydrazide derivatives as anti-bacterial agents". . p. 2267 - 2272. Retrieved 2015/12/01.