Technology Process of 6-(benzyloxy)-5,6,7,8-tetrahydro-5,8-methanoquinoline N-oxide
There total 11 articles about 6-(benzyloxy)-5,6,7,8-tetrahydro-5,8-methanoquinoline N-oxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 0 ℃;
DOI:10.1021/jo00232a029
- Guidance literature:
-
Multi-step reaction with 10 steps
1: MeONa/MeOH
2: 5.39 g / NaH, tetra-n-butylammonium iodide / tetrahydrofuran / 3 h / Heating
3: 1.) lithium diisopropylamide / 1.) hexane, THF, -30 deg C, 5 min, 2.) from -78 deg C to RT
4: 6.26 g / p-toluenesulfonic acid / toluene
5: 4.58 g / O3 / CH2Cl2 / -78 °C
6: 1.) n-butyllithium / 1.) THF, hexane, 0 deg C, 10 min, 2.) from -78 deg C to RT
7: 0.7 g / NH2OH, HCl / methanol; H2O / 0.5 h / Heating
8: 0.49 g / NH2OH*HCl, KOH / methanol / 0.5 h / Ambient temperature
9: 0.18 g / AcOH / 16 h / Heating
10: 4.9 g / m-chloroperbenzoic acid / CH2Cl2 / 0 °C
With
hydrogenchloride; methanol; potassium hydroxide; n-butyllithium; hydroxylamine hydrochloride; hydroxylamine; sodium methylate; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; ozone; acetic acid; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1021/jo00232a029
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 5.39 g / NaH, tetra-n-butylammonium iodide / tetrahydrofuran / 3 h / Heating
2: 1.) lithium diisopropylamide / 1.) hexane, THF, -30 deg C, 5 min, 2.) from -78 deg C to RT
3: 6.26 g / p-toluenesulfonic acid / toluene
4: 4.58 g / O3 / CH2Cl2 / -78 °C
5: 1.) n-butyllithium / 1.) THF, hexane, 0 deg C, 10 min, 2.) from -78 deg C to RT
6: 0.7 g / NH2OH, HCl / methanol; H2O / 0.5 h / Heating
7: 0.49 g / NH2OH*HCl, KOH / methanol / 0.5 h / Ambient temperature
8: 0.18 g / AcOH / 16 h / Heating
9: 4.9 g / m-chloroperbenzoic acid / CH2Cl2 / 0 °C
With
hydrogenchloride; potassium hydroxide; n-butyllithium; hydroxylamine hydrochloride; hydroxylamine; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; ozone; acetic acid; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1021/jo00232a029
