Unii-G9Z22EU5FK

Base Information

Chemical Name:Unii-G9Z22EU5FK
CAS No.:512784-94-0
Molecular Formula:C₄₃H₄₈F₃N₅O₅
Molecular Weight:771.88
Hs Code.:
UNII:G9Z22EU5FK
ChEMBL ID:CHEMBL279328
Pharos Ligand ID:34D3YUHPBH6Z

Synonyms:SRX 251;SRX-251;UNII-G9Z22EU5FK;512784-94-0;Srx-251(E-isomer);G9Z22EU5FK;CHEMBL279328;(2R)-N-Methyl-4-oxo-2-((3S,4R)-2-oxo-3-((4S)-2-oxo-4-phenyl-oxazolidin-3-yl)-4-((E)-styryl)azetidin-1-yl)-4-(4-(1-piperidyl)-1-piperidyl)-N-((3-(trifluoromethyl)phenyl)methyl)butanamide;(R)-4-([1,4'-bipiperidin]-1'-yl)-N-methyl-4-oxo-2-((3S,4R)-2-oxo-3-((S)-2-oxo-4-phenyloxazolidin-3-yl)-4-((E)-styryl)azetidin-1-yl)-N-(3-(trifluoromethyl)benzyl)butanamide;SCHEMBL14904494;GOQPVIZMGXUXOL-GRLAPFOSSA-N;BDBM50202860;NSC782567;AKOS040749561;NSC-782567;(.ALPHA.R)-N-METHYL-.GAMMA.-OXO-.ALPHA.-((3S,4R)-2-OXO-3-((4S)-2-OXO-4-PHENYL-3-OXAZOLIDINYL)-4-((1E)-2-PHENYLETHENYL)-1-AZETIDINYL)-N-((3-(TRIFLUOROMETHYL)PHENYL)METHYL)(1,4'-BIPIPERIDINE)-1'-BUTANAMIDE;(1,4'-BIPIPERIDINE)-1'-BUTANAMIDE, N-METHYL-.GAMMA.-OXO-.ALPHA.-((3S,4R)-2-OXO-3-((4S)-2-OXO-4-PHENYL-3-OXAZOLIDINYL)-4-((1E)-2-PHENYLETHENYL)-1-AZETIDINYL)-N-((3-(TRIFLUOROMETHYL)PHENYL)METHYL)-, (.ALPHA.R)-;(1,4'-Bipiperidine)-1'-butanamide, N-methyl-gamma-oxo-alpha-((3S,4R)-2-oxo-3-((4S)-2-oxo-4-phenyl-3-oxazolidinyl)-4-((1E)-2-phenylethenyl)-1-azetidinyl)-N-((3-(trifluoromethyl)phenyl)methyl)-, (alphaR)-;(2R)-N-methyl-4-oxo-2-[(3S,4R)-2-oxo-3-[(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]-4-[(E)-2-phenylethenyl]azetidin-1-yl]-4-(4-piperidin-1-ylpiperidin-1-yl)-N-[[3-(trifluoromethyl)phenyl]methyl]butanamide;(alphaR)-N-Methyl-gamma-oxo-alpha-((3S,4R)-2-oxo-3-((4S)-2-oxo-4-phenyl-3-oxazolidinyl)-4-((1E)-2-phenylethenyl)-1-azetidinyl)-N-((3-(trifluoromethyl)phenyl)methyl)(1,4'-bipiperidine)-1'-butanamide;2(R)-[[4-(piperidin-1-yl)piperidin-1-yl]carbonylmethyl]-2-[3(S)-(4(S)-phenyloxazolidin-2-on-3-yl)-4(R)-(2-styryl)azetidin-2-on-1-yl]acetic acid N-methyl-N-(3-trifluoromethylbenzyl)amide;911068-90-1

Suppliers and Price of Unii-G9Z22EU5FK

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Unii-G9Z22EU5FK

Chemical Property:

XLogP3:5.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:11
Exact Mass:771.36075413
Heavy Atom Count:56
Complexity:1400

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(CC1=CC(=CC=C1)C(F)(F)F)C(=O)C(CC(=O)N2CCC(CC2)N3CCCCC3)N4C(C(C4=O)N5C(COC5=O)C6=CC=CC=C6)C=CC7=CC=CC=C7
Isomeric SMILES:CN(CC1=CC(=CC=C1)C(F)(F)F)C(=O)[C@@H](CC(=O)N2CCC(CC2)N3CCCCC3)N4[C@@H]([C@@H](C4=O)N5[C@H](COC5=O)C6=CC=CC=C6)/C=C/C7=CC=CC=C7

Technology Process of Unii-G9Z22EU5FK

There total 9 articles about Unii-G9Z22EU5FK which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 512785-12-5
N-benzyloxycarbonyl-D-aspartic acid γ-tert-butyl ester α-[N-methyl-N-(3-trifluoromethylbenzyl)]amide

: 512784-94-0
SRX₂₅₁

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / hydrogen / palladium on carbon / methanol

2: magnesium sulfate / CH₂Cl₂ / 20 °C

3: 0.253 g / amine / CH₂Cl₂ / 1 h / 0 - 20 °C

4: 100 percent / formic acid / 20 °C

5: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; HOAt / CH₂Cl₂ / 20 °C

With formic acid; 1-hydroxy-7-aza-benzotriazole; hydrogen; magnesium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane; 3: Staudinger cycloaddition;
DOI:10.1016/j.bmc.2006.12.031

Reference yield:

: 90390-07-1
N-methyl-1-(3-(trifluoromethyl)phenyl)methanamine

: 512784-94-0
SRX₂₅₁

Guidance literature:: Multi-step reaction with 6 steps

1: 65 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; HOAt / CH₂Cl₂ / 20 °C

2: 95 percent / hydrogen / palladium on carbon / methanol

3: magnesium sulfate / CH₂Cl₂ / 20 °C

4: 0.253 g / amine / CH₂Cl₂ / 1 h / 0 - 20 °C

5: 100 percent / formic acid / 20 °C

6: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; HOAt / CH₂Cl₂ / 20 °C

With formic acid; 1-hydroxy-7-aza-benzotriazole; hydrogen; magnesium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane; 4: Staudinger cycloaddition;
DOI:10.1016/j.bmc.2006.12.031

Reference yield:

: 512785-30-7
N-methyl-3-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-succinamic acid

: 4897-50-1
4-piperidinopiperidin

: 512784-94-0
SRX₂₅₁

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2006.12.031