({4-[(6-cyclohexyl-5-hydroxypyridin-2-yl)methyl]-3,5-dimethylphenyl}amino)(oxo)acetic acid

Base Information

Chemical Name:({4-[(6-cyclohexyl-5-hydroxypyridin-2-yl)methyl]-3,5-dimethylphenyl}amino)(oxo)acetic acid
CAS No.:1253210-93-3
Molecular Formula:C₂₂H₂₆N₂O₄
Molecular Weight:382.459
Hs Code.:

Synonyms:({4-[(6-cyclohexyl-5-hydroxypyridin-2-yl)methyl]-3,5-dimethylphenyl}amino)(oxo)acetic acid

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Chemical Property of ({4-[(6-cyclohexyl-5-hydroxypyridin-2-yl)methyl]-3,5-dimethylphenyl}amino)(oxo)acetic acid

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Technology Process of ({4-[(6-cyclohexyl-5-hydroxypyridin-2-yl)methyl]-3,5-dimethylphenyl}amino)(oxo)acetic acid

There total 14 articles about ({4-[(6-cyclohexyl-5-hydroxypyridin-2-yl)methyl]-3,5-dimethylphenyl}amino)(oxo)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1253217-07-0
C₂₄H₃₀N₂O₄

: 1253210-93-3
({4-[(6-cyclohexyl-5-hydroxypyridin-2-yl)methyl]-3,5-dimethylphenyl}amino)(oxo)acetic acid

Guidance literature:: C₂₄H₃₀N₂O₄; With methanol; sodium hydroxide; In tetrahydrofuran;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 939430-71-4
6-chloro-5-methoxymethoxy-pyridine-2-carbaldehyde

: 1253210-93-3
({4-[(6-cyclohexyl-5-hydroxypyridin-2-yl)methyl]-3,5-dimethylphenyl}amino)(oxo)acetic acid

Guidance literature:: Multi-step reaction with 13 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 2.83 h / -78 - 20 °C

2.1: acetic acid / ethanol / 7 h / 50 °C

3.1: caesium carbonate / tetrahydrofuran; acetonitrile / 4 h

4.1: pyridine / 18 h

5.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 0.17 h / 0 °C / Cooling with ice

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; water / 24 h / 90 °C / Inert atmosphere

7.1: palladium 10% on activated carbon; hydrogen / ethanol / 9 h / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / Cooling with ice

9.1: palladium diacetate; caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / tetrahydrofuran / Inert atmosphere; Reflux

10.1: hydroxylamine hydrochloride; sodium acetate / methanol; N,N-dimethyl-formamide

11.1: triethylamine / dichloromethane / Cooling with ice

12.1: trifluorormethanesulfonic acid; methyl-phenyl-thioether / dichloromethane / 40 °C

13.1: methanol; sodium hydroxide / tetrahydrofuran

With pyridine; methanol; triethylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; trifluorormethanesulfonic acid; methyl-phenyl-thioether; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; hydrogen; sodium acetate; palladium diacetate; caesium carbonate; acetic acid; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 848442-41-1
C₁₂H₁₇BrO₂

: 1253210-93-3
({4-[(6-cyclohexyl-5-hydroxypyridin-2-yl)methyl]-3,5-dimethylphenyl}amino)(oxo)acetic acid

Guidance literature:: Multi-step reaction with 13 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 2.83 h / -78 - 20 °C

2.1: acetic acid / ethanol / 7 h / 50 °C

3.1: caesium carbonate / tetrahydrofuran; acetonitrile / 4 h

4.1: pyridine / 18 h

5.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 0.17 h / 0 °C / Cooling with ice

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; water / 24 h / 90 °C / Inert atmosphere

7.1: palladium 10% on activated carbon; hydrogen / ethanol / 9 h / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / Cooling with ice

9.1: palladium diacetate; caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl / tetrahydrofuran / Inert atmosphere; Reflux

10.1: hydroxylamine hydrochloride; sodium acetate / methanol; N,N-dimethyl-formamide

11.1: triethylamine / dichloromethane / Cooling with ice

12.1: trifluorormethanesulfonic acid; methyl-phenyl-thioether / dichloromethane / 40 °C

13.1: methanol; sodium hydroxide / tetrahydrofuran

With pyridine; methanol; triethylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; trifluorormethanesulfonic acid; methyl-phenyl-thioether; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; hydrogen; sodium acetate; palladium diacetate; caesium carbonate; acetic acid; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;