(4S,6S)-4-(2,4-difluoro-5-(2-fluoropyrimidin-5-yl)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

Base Information

Chemical Name:(4S,6S)-4-(2,4-difluoro-5-(2-fluoropyrimidin-5-yl)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
CAS No.:1616100-32-3
Molecular Formula:C₂₀H₁₈F₃N₅OS
Molecular Weight:433.457
Hs Code.:

Synonyms:(4S,6S)-4-(2,4-difluoro-5-(2-fluoropyrimidin-5-yl)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

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Chemical Property of (4S,6S)-4-(2,4-difluoro-5-(2-fluoropyrimidin-5-yl)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

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Technology Process of (4S,6S)-4-(2,4-difluoro-5-(2-fluoropyrimidin-5-yl)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

There total 6 articles about (4S,6S)-4-(2,4-difluoro-5-(2-fluoropyrimidin-5-yl)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.2%

: 1616100-83-4
tert-butyl ((4S,6S)-4-(2,4-difluoro-5-(2-fluoropyrimidin-5-yl)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-yl)carbamate

: 1616100-32-3
(4S,6S)-4-(2,4-difluoro-5-(2-fluoropyrimidin-5-yl)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1616100-82-3
(5-((4S,6S)-2-(tert-butoxycarbonylamino)-6-(3,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-2,4-difluorophenyl)boronic acid

: 1616100-32-3
(4S,6S)-4-(2,4-difluoro-5-(2-fluoropyrimidin-5-yl)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / 1,2-dimethoxyethane; ethanol; water / 0.17 h / 90 °C / Sealed tube

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; trifluoroacetic acid; In 1,2-dimethoxyethane; ethanol; dichloromethane; water;

Reference yield:

: 1616101-02-0
(3S)-3-amino-3-(5-bromo-2,4-difluorophenyl)-1-(3,5-dimethylisoxazol-4-yl)butan-1-ol

: 1616100-32-3
(4S,6S)-4-(2,4-difluoro-5-(2-fluoropyrimidin-5-yl)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: dichloromethane / 0.5 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 3 h / 95 °C

3: sodium hydrogencarbonate / water; 1,4-dioxane / 12 h / 20 °C

4: n-butyllithium / tetrahydrofuran / 0.1 h / -78 °C

5: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / 1,2-dimethoxyethane; ethanol; water / 0.17 h / 90 °C / Sealed tube

6: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; sodium hydrogencarbonate; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water;