trifluoromethanesulfonic acid 1-[4-((R)-2-ethyl-2-hydroxy-1-phenylbutylamino)phthalazin-1-yl]-7-methoxynaphthalen-2-yl ester

Base Information

Chemical Name:trifluoromethanesulfonic acid 1-[4-((R)-2-ethyl-2-hydroxy-1-phenylbutylamino)phthalazin-1-yl]-7-methoxynaphthalen-2-yl ester
CAS No.:862123-05-5
Molecular Formula:C₃₂H₃₀F₃N₃O₅S
Molecular Weight:625.669
Hs Code.:

Synonyms:trifluoromethanesulfonic acid 1-[4-((R)-2-ethyl-2-hydroxy-1-phenylbutylamino)phthalazin-1-yl]-7-methoxynaphthalen-2-yl ester

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Chemical Property of trifluoromethanesulfonic acid 1-[4-((R)-2-ethyl-2-hydroxy-1-phenylbutylamino)phthalazin-1-yl]-7-methoxynaphthalen-2-yl ester

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Technology Process of trifluoromethanesulfonic acid 1-[4-((R)-2-ethyl-2-hydroxy-1-phenylbutylamino)phthalazin-1-yl]-7-methoxynaphthalen-2-yl ester

There total 4 articles about trifluoromethanesulfonic acid 1-[4-((R)-2-ethyl-2-hydroxy-1-phenylbutylamino)phthalazin-1-yl]-7-methoxynaphthalen-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 862123-04-4
trifluoromethanesulfonic acid 1-(4-chlorophthalazin-1-yl)-7-methoxynaphthalen-2-yl ester

: 180569-48-6
(R)-3-(amino-phenyl-methyl)pentan-3-ol

: 862123-05-5
trifluoromethanesulfonic acid 1-[4-((R)-2-ethyl-2-hydroxy-1-phenylbutylamino)phthalazin-1-yl]-7-methoxynaphthalen-2-yl ester

Guidance literature:: at 120 ℃; for 18h;
DOI:10.1021/ja052411r

Reference yield:

: 862123-03-3
1-(4-chlorophthalazin-1-yl)-7-methoxynaphthalen-2-ol

: 862123-05-5
trifluoromethanesulfonic acid 1-[4-((R)-2-ethyl-2-hydroxy-1-phenylbutylamino)phthalazin-1-yl]-7-methoxynaphthalen-2-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

2: 70 percent / 18 h / 120 °C

With pyridine; In dichloromethane;
DOI:10.1021/ja052411r

Reference yield:

: 4752-10-7
1,4-dichlorophthalazine

: 862123-05-5
trifluoromethanesulfonic acid 1-[4-((R)-2-ethyl-2-hydroxy-1-phenylbutylamino)phthalazin-1-yl]-7-methoxynaphthalen-2-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / AlCl₃ / 1,2-dichloro-ethane / 20 h / 80 °C

2: 88 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

3: 70 percent / 18 h / 120 °C

With pyridine; aluminium trichloride; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ja052411r