sodium 3(R),5(R)-dihydroxy-7-<1-phenyl-2-isopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

Base Information

Chemical Name:sodium 3(R),5(R)-dihydroxy-7-<1-phenyl-2-isopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate
CAS No.:124508-41-4
Molecular Formula:C₂₆H₂₉FNO₄*Na
Molecular Weight:461.509
Hs Code.:

Synonyms:sodium 3(R),5(R)-dihydroxy-7-<1-phenyl-2-isopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

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Chemical Property of sodium 3(R),5(R)-dihydroxy-7-<1-phenyl-2-isopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

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Technology Process of sodium 3(R),5(R)-dihydroxy-7-<1-phenyl-2-isopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

There total 21 articles about sodium 3(R),5(R)-dihydroxy-7-<1-phenyl-2-isopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.8%

: 124401-67-8
tert-butyl 3(R),5(R)-dihydroxy-7-<1-phenyl-2-isopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

: 124508-41-4
sodium 3(R),5(R)-dihydroxy-7-<1-phenyl-2-isopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

Guidance literature:: With sodium hydroxide; In ethanol; for 20h; Ambient temperature;
DOI:10.1021/jm00163a011

Reference yield:

: 122223-48-7
3-(phenylamino)-4-methylpent-2(E)-enoic acid anilide

: 124508-41-4
sodium 3(R),5(R)-dihydroxy-7-<1-phenyl-2-isopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

Guidance literature:: Multi-step reaction with 11 steps

1: 78 percent / ethanol / 12 h / Heating

2: 1.) NaH / 1a.) toluene, 60 deg C, 30 min, 1b.) 100 deg C, 10 min, 2.) reflux

3: 92 percent / lithium aluminum hydride / tetrahydrofuran / 20 h / Heating

4: 87 percent / N-methylmorpholine N-oxide, tris(triphenylphosphine)ruthenium(II) dichloride / acetone / 20 h / Ambient temperature

6: 1.) LDA / 1.) THF, 0 deg C, 30 min, 2.) -90 deg C, 2 h

7: methanol / 3 h / Ambient temperature

8: 1.) LDA / 1.) THF, hexane, -70 deg C, 40 min, 2a.) 10 min, 2b.) -30 deg C, 1 h

9: 1.) triethylborane, 2.) sodium borohydride / 1.) THF, -70 deg C, 1 h, 2.) -70 deg C, 1.5 h

10: H₂, triethylamine / 10percent Pd/C / methanol / 0.33 h / Ambient temperature

11: 99.8 percent / 1 N sodium hydroxide / ethanol / 20 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; tris(triphenylphosphine)ruthenium(II) chloride; triethyl borane; hydrogen; sodium hydride; 4-methylmorpholine N-oxide; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; acetone;
DOI:10.1021/jm00163a011

Reference yield:

: 122223-48-7
3-(phenylamino)-4-methylpent-2(E)-enoic acid anilide

: 122223-42-1,124508-41-4
sodium 3(RS),5(RS)-dihydroxy-7-<1-phenyl-2-isopropyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

Guidance literature:: Multi-step reaction with 9 steps

1: 78 percent / ethanol / 12 h / Heating

2: 1.) NaH / 1a.) toluene, 60 deg C, 30 min, 1b.) 100 deg C, 10 min, 2.) reflux

3: 92 percent / lithium aluminum hydride / tetrahydrofuran / 20 h / Heating

4: 87 percent / N-methylmorpholine N-oxide, tris(triphenylphosphine)ruthenium(II) dichloride / acetone / 20 h / Ambient temperature

7: 1.) 1 M triethylborane, 2.) sodium borohydride / 1.) THF, 20 deg C, 140 min, 2.) -75 deg C, 12 h

8: H₂, triethylamine / 10percent Pd/C / methanol / 0.33 h / Ambient temperature

9: 1.) 1 N aq. sodium hydroxide / 1.) methanol, 0 deg C, 1 h, 2.) RT, 1 h

With sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; tris(triphenylphosphine)ruthenium(II) chloride; triethyl borane; hydrogen; sodium hydride; 4-methylmorpholine N-oxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; acetone;
DOI:10.1021/jm00163a011