isopropyl 2-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

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Chemical Name:isopropyl 2-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate
CAS No.:1454288-96-0
Molecular Formula:C₂₀H₁₉F₃N₂O₄S₂
Molecular Weight:472.509
Hs Code.:

Synonyms:isopropyl 2-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

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Chemical Property of isopropyl 2-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

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Technology Process of isopropyl 2-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

There total 5 articles about isopropyl 2-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 918328-00-4
2-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid

: 67-63-0,8013-70-5
isopropyl alcohol

: 1454288-96-0
isopropyl 2-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

Guidance literature:: With sulfuric acid; at 90 ℃; for 16h;

Reference yield:

: 5370-25-2
2-Acetyl-5-bromothiophene

: 1454288-96-0
isopropyl 2-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: methanol / 1.5 h / Reflux

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

4.1: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

5.1: sulfuric acid / 16 h / 90 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; water; sodium carbonate; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 326-71-6
1-(5-bromothiophen-2-yl)-4,4,4-trifluorobutane-1,3-dione

: 1454288-96-0
isopropyl 2-(5-(5-(3-(methylsulfonyl)phenyl)thiophen-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 1.5 h / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

3: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

4: sulfuric acid / 16 h / 90 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; water; sodium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;