N-[2-(1H-Benzoimidazole-2-sulfinylmethyl)-phenyl]-2-(4-methyl-piperazin-1-yl)-acetamide

Base Information

Chemical Name:N-[2-(1H-Benzoimidazole-2-sulfinylmethyl)-phenyl]-2-(4-methyl-piperazin-1-yl)-acetamide
CAS No.:111908-70-4
Molecular Formula:C₂₁H₂₅N₅O₂S
Molecular Weight:411.528
Hs Code.:

Synonyms:N-[2-(1H-Benzoimidazole-2-sulfinylmethyl)-phenyl]-2-(4-methyl-piperazin-1-yl)-acetamide

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Chemical Property of N-[2-(1H-Benzoimidazole-2-sulfinylmethyl)-phenyl]-2-(4-methyl-piperazin-1-yl)-acetamide

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Technology Process of N-[2-(1H-Benzoimidazole-2-sulfinylmethyl)-phenyl]-2-(4-methyl-piperazin-1-yl)-acetamide

There total 7 articles about N-[2-(1H-Benzoimidazole-2-sulfinylmethyl)-phenyl]-2-(4-methyl-piperazin-1-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.9%

: 109-01-3
1-methyl-piperazine

: 111908-66-8
2-<(2-chloracetaminobenzyl)sulfinyl>-1H-benzimidazole

: 111908-70-4
N-[2-(1H-Benzoimidazole-2-sulfinylmethyl)-phenyl]-2-(4-methyl-piperazin-1-yl)-acetamide

Guidance literature:: With potassium iodide; In methanol; chloroform; for 6h; Ambient temperature;
DOI:10.1016/0223-5234(91)90024-H

Reference yield:

: 5344-90-1
2-Aminobenzyl alcohol

: 111908-70-4
N-[2-(1H-Benzoimidazole-2-sulfinylmethyl)-phenyl]-2-(4-methyl-piperazin-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 82.4 percent / K₂CO₃ / CHCl₃ / 1.) 4 h, 2.) RT, overnight

2: SOCl₂ / benzene / 1 h / Heating

3: NaOH / H₂O; ethanol / 2 h / Ambient temperature

4: 84.4 percent / 30percent HBr-AcOH / 3 h / Ambient temperature

5: 42.4 percent / K₂CO₃ / dimethylformamide / 2 h / Ambient temperature

6: 88.5 percent / m-chloroperbenzoic acid / CHCl₃; methanol / 0.67 h / 0 °C

7: 90.9 percent / KI / CHCl₃; methanol / 6 h / Ambient temperature

With sodium hydroxide; thionyl chloride; hydrogen bromide; potassium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; potassium iodide; In methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; benzene;
DOI:10.1016/0223-5234(91)90024-H

Reference yield:

: 104340-33-2
2-<(1H-benzimidazol-2-ylthio)methyl>aniline

: 111908-70-4
N-[2-(1H-Benzoimidazole-2-sulfinylmethyl)-phenyl]-2-(4-methyl-piperazin-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 42.4 percent / K₂CO₃ / dimethylformamide / 2 h / Ambient temperature

2: 88.5 percent / m-chloroperbenzoic acid / CHCl₃; methanol / 0.67 h / 0 °C

3: 90.9 percent / KI / CHCl₃; methanol / 6 h / Ambient temperature

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium iodide; In methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(91)90024-H