8-((3,5-difluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Base Information

Chemical Name:8-((3,5-difluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one
CAS No.:1420367-28-7
Molecular Formula:C₂₁H₁₇F₅N₄O₃
Molecular Weight:468.383
Hs Code.:

Synonyms:8-((3,5-difluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Suppliers and Price of 8-((3,5-difluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Lp-PLA2-IN-1(GSK2814338) >98%
250 mg
$ 1400.00

DC Chemicals
Lp-PLA2-IN-1(GSK2814338) >98%
1 g
$ 2700.00

ChemScene
Lp-PLA2-IN-1 99.46%
100mg
$ 2520.00

ChemScene
Lp-PLA2-IN-1 99.46%
50mg
$ 1800.00

ChemScene
Lp-PLA2-IN-1 99.46%
10mg
$ 600.00

ChemScene
Lp-PLA2-IN-1 99.46%
5mg
$ 420.00

ChemScene
Lp-PLA2-IN-1 99.46%
1mg
$ 168.00

Total 6 raw suppliers

Chemical Property of 8-((3,5-difluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Lp-PLA2-IN-1(GSK2814338) >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-((3,5-difluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

There total 7 articles about 8-((3,5-difluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1369256-71-2
(3,5-difluoro-4-((6-(trifluoromethyl)-3-pyridinyl)oxy)phenyl)methanol

: 1420362-25-9
8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt

: 1420367-28-7
8-((3,5-difluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

Reference yield: 28.0%

: 1420367-28-7
8-((3,5-difluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

: 1420362-15-7
6-((3-hydroxypropyl)(methyl)amino)pyrimidine-2,4(1H,3H)-dione trifluoroacetic acid salt

: 1420367-28-7
8-((3,5-difluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 20 °C

2: trichlorophosphate / 6 h / 90 °C

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

With di-isopropyl azodicarboxylate; sodium hydride; triphenylphosphine; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; 1: |Mitsunobu Displacement;