tert-butyl 3-{3-[1-(4-amino-3-formyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl}azetidine-1-carboxylate

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Chemical Name:tert-butyl 3-{3-[1-(4-amino-3-formyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl}azetidine-1-carboxylate
CAS No.:1426699-52-6
Molecular Formula:C₂₃H₂₆ClFN₆O₄
Molecular Weight:504.949
Hs Code.:

Synonyms:tert-butyl 3-{3-[1-(4-amino-3-formyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl}azetidine-1-carboxylate

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Chemical Property of tert-butyl 3-{3-[1-(4-amino-3-formyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl}azetidine-1-carboxylate

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Technology Process of tert-butyl 3-{3-[1-(4-amino-3-formyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl}azetidine-1-carboxylate

There total 10 articles about tert-butyl 3-{3-[1-(4-amino-3-formyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl}azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1426699-51-5
tert-butyl 3-(3-{1-[4-amino-3-(1,2-dihydroxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl}-5-chloro-6-fluoro-2-methoxyphenyl)azetidine-1-carboxylate

: 1426699-52-6
tert-butyl 3-{3-[1-(4-amino-3-formyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl}azetidine-1-carboxylate

Guidance literature:: With sodium periodate; acetic acid; In tetrahydrofuran; water; at 0 ℃; for 2h;

Reference yield:

: 1382996-85-1
tert-butyl 3-[3-chloro-2-fluoro-5-(1-hydroxyethyl)-6-methoxyphenyl]azetidine-1-carboxylate

: 1426699-52-6
tert-butyl 3-{3-[1-(4-amino-3-formyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl}azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide / dichloromethane / 20 °C

2: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 3 h / 140 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide; water / 100 °C / Inert atmosphere

4: osmium(VIII) oxide; 4-methylmorpholine N-oxide; water / tert-butyl alcohol / 20 °C

5: sodium periodate; acetic acid / water; tetrahydrofuran / 2 h / 0 °C

With sodium periodate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3,5-trichloro-2,4,6-triazine; water; sodium carbonate; caesium carbonate; acetic acid; 4-methylmorpholine N-oxide; N,N-dimethyl-formamide; potassium iodide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 865451-01-0
1-(5-chloro-4-fluoro-2-hydroxyphenyl)ethan-1-one

: 1426699-52-6
tert-butyl 3-{3-[1-(4-amino-3-formyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-6-fluoro-2-methoxyphenyl}azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-iodo-succinimide / acetic acid / 2 h / 70 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

3.1: zinc; chloro-trimethyl-silane; ethylene dibromide / N,N-dimethyl-formamide / 1 h / 40 °C

3.2: 70 °C

4.1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

5.1: 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide / dichloromethane / 20 °C

6.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 3 h / 140 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide; water / 100 °C / Inert atmosphere

8.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide; water / tert-butyl alcohol / 20 °C

9.1: sodium periodate; acetic acid / water; tetrahydrofuran / 2 h / 0 °C

With methanol; sodium tetrahydroborate; sodium periodate; N-iodo-succinimide; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; chloro-trimethyl-silane; 1,3,5-trichloro-2,4,6-triazine; water; sodium carbonate; potassium carbonate; caesium carbonate; acetic acid; 4-methylmorpholine N-oxide; ethylene dibromide; N,N-dimethyl-formamide; potassium iodide; zinc; In tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol;