(2R,5S)-2-Benzyl-5-tert-butoxycarbonylamino-6-methyl-4-oxo-heptanoic acid

Base Information

Chemical Name:(2R,5S)-2-Benzyl-5-tert-butoxycarbonylamino-6-methyl-4-oxo-heptanoic acid
CAS No.:151011-85-7
Molecular Formula:C₂₀H₂₉NO₅
Molecular Weight:363.454
Hs Code.:

Synonyms:(2R,5S)-2-Benzyl-5-tert-butoxycarbonylamino-6-methyl-4-oxo-heptanoic acid

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Chemical Property of (2R,5S)-2-Benzyl-5-tert-butoxycarbonylamino-6-methyl-4-oxo-heptanoic acid

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Technology Process of (2R,5S)-2-Benzyl-5-tert-butoxycarbonylamino-6-methyl-4-oxo-heptanoic acid

There total 12 articles about (2R,5S)-2-Benzyl-5-tert-butoxycarbonylamino-6-methyl-4-oxo-heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R,5S)-2-Benzyl-5-benzyloxycarbonylamino-6-methyl-4-oxo-heptanoic acid benzyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 151011-85-7
(2R,5S)-2-Benzyl-5-tert-butoxycarbonylamino-6-methyl-4-oxo-heptanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 10h;
DOI:10.1021/jm050184y

Reference yield:

: 869494-47-3
(2R,4S,5S)-2-Benzyl-5-tert-butoxycarbonylamino-4-hydroxy-6-methyl-heptanoic acid

: 151011-85-7
(2R,5S)-2-Benzyl-5-tert-butoxycarbonylamino-6-methyl-4-oxo-heptanoic acid

Guidance literature:: With tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide; In dichloromethane; at 23 ℃; for 1.33h;
DOI:10.1021/jm980537b

Reference yield:

: 111437-25-3
benzyl (R)-(+)-3-phenyl-2-(trifluoromethylsulfonyloxy)propanoate

: 151011-85-7
(2R,5S)-2-Benzyl-5-tert-butoxycarbonylamino-6-methyl-4-oxo-heptanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 24 h / 0 - 20 °C

1.2: CF₃COOH / CH₂Cl₂ / 24 h / 20 °C

2.1: H₂ / Pd/C / methanol / 10 h / 20 °C

With hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm050184y