(R)-[5-[(benzyloxycarbonyl)amino]-6-oxo-2-(phenyl)-1,6-dihydro-1-pyrimidinyl]-N-(tetrahydronaphthyl)acetamide

Base Information

Chemical Name:(R)-[5-[(benzyloxycarbonyl)amino]-6-oxo-2-(phenyl)-1,6-dihydro-1-pyrimidinyl]-N-(tetrahydronaphthyl)acetamide
CAS No.:1033000-39-3
Molecular Formula:C₃₀H₂₈N₄O₄
Molecular Weight:508.577
Hs Code.:

Synonyms:(R)-[5-[(benzyloxycarbonyl)amino]-6-oxo-2-(phenyl)-1,6-dihydro-1-pyrimidinyl]-N-(tetrahydronaphthyl)acetamide

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Chemical Property of (R)-[5-[(benzyloxycarbonyl)amino]-6-oxo-2-(phenyl)-1,6-dihydro-1-pyrimidinyl]-N-(tetrahydronaphthyl)acetamide

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Technology Process of (R)-[5-[(benzyloxycarbonyl)amino]-6-oxo-2-(phenyl)-1,6-dihydro-1-pyrimidinyl]-N-(tetrahydronaphthyl)acetamide

There total 1 articles about (R)-[5-[(benzyloxycarbonyl)amino]-6-oxo-2-(phenyl)-1,6-dihydro-1-pyrimidinyl]-N-(tetrahydronaphthyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 23357-46-2
(R)-1,2,3,4-Tetrahydro-1-naphthylamine

: 148747-59-5
5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-ylmethylcarboxylic acid

: 1033000-39-3
(R)-[5-[(benzyloxycarbonyl)amino]-6-oxo-2-(phenyl)-1,6-dihydro-1-pyrimidinyl]-N-(tetrahydronaphthyl)acetamide

Guidance literature:: 5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-ylmethylcarboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In water; N,N-dimethyl-formamide; for 0.5h;

(R)-1,2,3,4-Tetrahydro-1-naphthylamine; In water; N,N-dimethyl-formamide; for 16h;

Reference yield: 95.0%

: 1033000-39-3
(R)-[5-[(benzyloxycarbonyl)amino]-6-oxo-2-(phenyl)-1,6-dihydro-1-pyrimidinyl]-N-(tetrahydronaphthyl)acetamide

: 1033000-40-6
(R)-(5-amino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(tetrahydronaphthyl)acetamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; for 4h; under 2327.23 Torr;

Reference yield:

: 1033000-39-3
(R)-[5-[(benzyloxycarbonyl)amino]-6-oxo-2-(phenyl)-1,6-dihydro-1-pyrimidinyl]-N-(tetrahydronaphthyl)acetamide

: 1032998-52-9
(S)-2-methylamino-N-(6-oxo-2-phenyl-1-{[(R)-(1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl]methyl}-1,6-dihydropyrimidin-5-yl)propionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 2327.23 Torr

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h

2.2: 16 h

2.3: 10 h

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In ethanol; N,N-dimethyl-formamide;