N-(diethylphosphoryl)-L-isoleucyl-L-alanylglycyl-5-benzyl-L-glutamyl-N^G-nitro-L-arginylglycine benzyl ester

Base Information

• Chemical Name: N-(diethylphosphoryl)-L-isoleucyl-L-alanylglycyl-5-benzyl-L-glutamyl-N^G-nitro-L-arginylglycine benzyl ester
• CAS No.: 122900-23-6
• Molecular Formula: C₄₂H₆₃N₁₀O₁₄P
• Molecular Weight: 962.995

Synonyms:N-(diethylphosphoryl)-L-isoleucyl-L-alanylglycyl-5-benzyl-L-glutamyl-N^G-nitro-L-arginylglycine benzyl ester

Chemical Property of N-(diethylphosphoryl)-L-isoleucyl-L-alanylglycyl-5-benzyl-L-glutamyl-N^G-nitro-L-arginylglycine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(diethylphosphoryl)-L-isoleucyl-L-alanylglycyl-5-benzyl-L-glutamyl-N^G-nitro-L-arginylglycine benzyl ester

There total 4 articles about N-(diethylphosphoryl)-L-isoleucyl-L-alanylglycyl-5-benzyl-L-glutamyl-N^G-nitro-L-arginylglycine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(diethylphosphoryl)-L-isoleucine (122899-90-5) → N-(diethylphosphoryl)-L-isoleucyl-L-alanylglycyl-5-benzyl-L-glutamyl-NG-nitro-L-arginylglycine benzyl ester (122900-23-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-hydroxybenzotriazole, DCC / dimethylformamide / 10 h / 4 °C

2: H₂ / 10percent Pd/C / methanol / 1 h / 760 Torr

3: 1.) HOBt, DCC, 2.) Et₃N / 1.) DMF, 0 deg C, 2.) overnight

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00163a044

Reference yield:

H-Ala-Gly-OBzl (66285-47-0) → N-(diethylphosphoryl)-L-isoleucyl-L-alanylglycyl-5-benzyl-L-glutamyl-NG-nitro-L-arginylglycine benzyl ester (122900-23-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-hydroxybenzotriazole, DCC / dimethylformamide / 10 h / 4 °C

2: H₂ / 10percent Pd/C / methanol / 1 h / 760 Torr

3: 1.) HOBt, DCC, 2.) Et₃N / 1.) DMF, 0 deg C, 2.) overnight

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00163a044

Reference yield:

(2S,3S)-2-(Diethoxy-phosphorylamino)-3-methyl-pentanoic acid benzyl ester (122900-74-7) → N-(diethylphosphoryl)-L-isoleucyl-L-alanylglycyl-5-benzyl-L-glutamyl-NG-nitro-L-arginylglycine benzyl ester (122900-23-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / H₂ / 10percent Pd/C / methanol / 760 Torr

2: 1-hydroxybenzotriazole, DCC / dimethylformamide / 10 h / 4 °C

3: H₂ / 10percent Pd/C / methanol / 1 h / 760 Torr

4: 1.) HOBt, DCC, 2.) Et₃N / 1.) DMF, 0 deg C, 2.) overnight

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00163a044

upstream raw materials:

N-(diethylphosphoryl)-L-isoleucine

H-Ala-Gly-OBzl

(2S,3S)-2-(Diethoxy-phosphorylamino)-3-methyl-pentanoic acid benzyl ester

{(S)-2-[(2S,3S)-2-(Diethoxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetic acid benzyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 122900-23-6 N-(diethylphosphoryl)-L-isoleucyl-L-alanylglycyl-5-benzyl-L-glutamyl-N^G-nitro-L-arginylglycine benzyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send