2-methylpropane-1-sulfonic acid methyl-{4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide

Base Information

Chemical Name:2-methylpropane-1-sulfonic acid methyl-{4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide
CAS No.:740873-27-2
Molecular Formula:C₁₉H₃₂N₄O₄S
Molecular Weight:412.553
Hs Code.:

Synonyms:2-methylpropane-1-sulfonic acid methyl-{4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide

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Chemical Property of 2-methylpropane-1-sulfonic acid methyl-{4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide

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Technology Process of 2-methylpropane-1-sulfonic acid methyl-{4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide

There total 6 articles about 2-methylpropane-1-sulfonic acid methyl-{4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: methyl-{4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amine tris-trifluoroacetic acid salt

: 35432-36-1
2-methylpropane-1-sulfonyl chloride

: 740873-27-2
2-methylpropane-1-sulfonic acid methyl-{4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jm0508641

Reference yield:

: 54054-85-2
1-(3-nitrophenyl)piperazine

: 740873-27-2
2-methylpropane-1-sulfonic acid methyl-{4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / Et₃N / tetrahydrofuran / 48 h / 20 °C

2: CH₂Cl₂ / 2 h / 0 °C

3: 75 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

With triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0508641

Reference yield:

: 200563-87-7
toluene-4-sulfonic acid 4-(tert-butoxycarbonylmethylamino)butyl ester

: 740873-27-2
2-methylpropane-1-sulfonic acid methyl-{4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / Et₃N / tetrahydrofuran / 48 h / 20 °C

2: CH₂Cl₂ / 2 h / 0 °C

3: 75 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

With triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0508641