2-[(R)-1-((S)-2-tert-Butoxycarbonylamino-2-carbamoyl-ethylamino)-3-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-propyl]-6-dimethylamino-5-methyl-pyrimidine-4-carboxylic acid ethyl ester

Base Information

Chemical Name:2-[(R)-1-((S)-2-tert-Butoxycarbonylamino-2-carbamoyl-ethylamino)-3-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-propyl]-6-dimethylamino-5-methyl-pyrimidine-4-carboxylic acid ethyl ester
CAS No.:201026-99-5
Molecular Formula:C₃₁H₄₃N₇O₈
Molecular Weight:641.725
Hs Code.:

2-[(R)-1-((S)-2-tert-Butoxycarbonylamino-2-carbamoyl-ethylamino)-3-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-propyl]-6-dimethylamino-5-methyl-pyrimidine-4-carboxylic acid ethyl ester

Synonyms:2-[(R)-1-((S)-2-tert-Butoxycarbonylamino-2-carbamoyl-ethylamino)-3-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-propyl]-6-dimethylamino-5-methyl-pyrimidine-4-carboxylic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[(R)-1-((S)-2-tert-Butoxycarbonylamino-2-carbamoyl-ethylamino)-3-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-propyl]-6-dimethylamino-5-methyl-pyrimidine-4-carboxylic acid ethyl ester

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-[(R)-1-((S)-2-tert-Butoxycarbonylamino-2-carbamoyl-ethylamino)-3-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-propyl]-6-dimethylamino-5-methyl-pyrimidine-4-carboxylic acid ethyl ester

There total 11 articles about 2-[(R)-1-((S)-2-tert-Butoxycarbonylamino-2-carbamoyl-ethylamino)-3-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-propyl]-6-dimethylamino-5-methyl-pyrimidine-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 201026-95-1
2-[(1S,2S)-1-((S)-2-tert-Butoxycarbonylamino-2-carbamoyl-ethylamino)-3-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-2-methylsulfanyl-3-oxo-propyl]-6-dimethylamino-5-methyl-pyrimidine-4-carboxylic acid ethyl ester

: 201026-99-5
2-[(R)-1-((S)-2-tert-Butoxycarbonylamino-2-carbamoyl-ethylamino)-3-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-propyl]-6-dimethylamino-5-methyl-pyrimidine-4-carboxylic acid ethyl ester

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; at 80 ℃; for 1h;
DOI:10.1021/ja971889v

Reference yield:

: 898-22-6
triethyl 1,3,5-triazine-2,4,6-tricarboxylate

: 201026-99-5
2-[(R)-1-((S)-2-tert-Butoxycarbonylamino-2-carbamoyl-ethylamino)-3-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-propyl]-6-dimethylamino-5-methyl-pyrimidine-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 69 percent / dioxane / 0 - 100 °C

2: NaBH₄ / ethanol

3: 70 percent / Pyr-SO₃, Et₃N / dimethylsulfoxide; CH₂Cl₂ / 1 h / 0 °C

4: 100 percent / acetonitrile / 1 h / 23 °C

5: 1.)Sn(OTf)2 / 1.) THF, -20 deg C, 1h, 2.) THF, 0 deg C, 7.5 h

6: 92 percent / Bu₃SnH, AIBN / benzene / 1 h / 80 °C

With sodium tetrahydroborate; tin(II) trifluoromethanesulfonate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sulfur trioxide pyridine complex; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile; benzene;
DOI:10.1021/ja971889v

Reference yield:

: 19006-23-6
1-dimethylaminopropyne

: 201026-99-5
2-[(R)-1-((S)-2-tert-Butoxycarbonylamino-2-carbamoyl-ethylamino)-3-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-3-oxo-propyl]-6-dimethylamino-5-methyl-pyrimidine-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 69 percent / dioxane / 0 - 100 °C

2: NaBH₄ / ethanol

3: 70 percent / Pyr-SO₃, Et₃N / dimethylsulfoxide; CH₂Cl₂ / 1 h / 0 °C

4: 100 percent / acetonitrile / 1 h / 23 °C

5: 1.)Sn(OTf)2 / 1.) THF, -20 deg C, 1h, 2.) THF, 0 deg C, 7.5 h

6: 92 percent / Bu₃SnH, AIBN / benzene / 1 h / 80 °C

With sodium tetrahydroborate; tin(II) trifluoromethanesulfonate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sulfur trioxide pyridine complex; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile; benzene;
DOI:10.1021/ja971889v