2-{4-[4-(4-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-phenylethynyl)-2,5-dimethoxy-phenylethynyl]-phenyl}-ethanol

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Chemical Name:2-{4-[4-(4-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-phenylethynyl)-2,5-dimethoxy-phenylethynyl]-phenyl}-ethanol
CAS No.:331735-30-9
Molecular Formula:C₄₉H₄₄O₆
Molecular Weight:728.885
Hs Code.:

Synonyms:2-{4-[4-(4-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-phenylethynyl)-2,5-dimethoxy-phenylethynyl]-phenyl}-ethanol

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Chemical Property of 2-{4-[4-(4-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-phenylethynyl)-2,5-dimethoxy-phenylethynyl]-phenyl}-ethanol

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Technology Process of 2-{4-[4-(4-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-phenylethynyl)-2,5-dimethoxy-phenylethynyl]-phenyl}-ethanol

There total 6 articles about 2-{4-[4-(4-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-phenylethynyl)-2,5-dimethoxy-phenylethynyl]-phenyl}-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 331735-29-6
2-(4-{4-[4-(2-hydroxy-ethyl)-phenylethynyl]-2,5-dimethoxy-phenylethynyl}-phenyl)-ethanol

: 331735-30-9
2-{4-[4-(4-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-phenylethynyl)-2,5-dimethoxy-phenylethynyl]-phenyl}-ethanol

Guidance literature:: With pyridine; at 20 ℃; for 6h;
DOI:10.1021/ja000950k

Reference yield:

: 331735-31-0
2-(4-((trimethylsilyl)ethynyl)phenyl)ethan-1-ol

: 331735-30-9
2-{4-[4-(4-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-phenylethynyl)-2,5-dimethoxy-phenylethynyl]-phenyl}-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / K₂CO₃ / methanol

2: 75 percent / PdCl₂(PPh₃)2; CuI; piperidine / 10 h / 20 °C

3: 42 percent / pyridine / 6 h / 20 °C

With piperidine; pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; In methanol;
DOI:10.1021/ja000950k

Reference yield:

: 103-82-2
phenylacetic acid

: 331735-30-9
2-{4-[4-(4-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-phenylethynyl)-2,5-dimethoxy-phenylethynyl]-phenyl}-ethanol

Guidance literature:: Multi-step reaction with 6 steps

1: 45 percent / iodine; 70percent HNO₃; H₂SO₄ conc. / acetic acid / 1.5 h / 60 °C

2: 79 percent / BH₃-Me₂S / diethyl ether / 8 h / Heating

3: 99 percent / PdCl₂(PPh₃)2; CuI; piperidine / 3 h

4: 95 percent / K₂CO₃ / methanol

5: 75 percent / PdCl₂(PPh₃)2; CuI; piperidine / 10 h / 20 °C

6: 42 percent / pyridine / 6 h / 20 °C

With piperidine; pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dimethylsulfide borane complex; sulfuric acid; iodine; potassium carbonate; In methanol; diethyl ether; acetic acid;
DOI:10.1021/ja000950k