1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(3-fluoro-4-formylphenyl)urea

Base Information

Chemical Name:1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(3-fluoro-4-formylphenyl)urea
CAS No.:1402582-07-3
Molecular Formula:C₁₉H₁₃ClF₄N₄O₂
Molecular Weight:440.784
Hs Code.:

Synonyms:1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(3-fluoro-4-formylphenyl)urea

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Chemical Property of 1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(3-fluoro-4-formylphenyl)urea

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Technology Process of 1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(3-fluoro-4-formylphenyl)urea

There total 9 articles about 1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(3-fluoro-4-formylphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1402581-32-1
1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-methyl]-3-[3-fluoro-4-(hydroxymethyl)-phenyl]-urea

: 1402582-07-3
1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(3-fluoro-4-formylphenyl)urea

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 ℃; for 1.5h;

Reference yield:

: 403-24-7
2-fluoro-4-nitrobenzoic acid

: 1402582-07-3
1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(3-fluoro-4-formylphenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / Reflux

2: sodium tetrahydroborate; methanol / 4 h / 23 °C

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 6 h / 23 °C

4: pyridine / acetone / 1 h / 0 - 23 °C

5: triethylamine / dichloromethane / 16 h / 23 °C

6: Dess-Martin periodane / dichloromethane / 1.5 h / 0 °C

With pyridine; methanol; sodium tetrahydroborate; sulfuric acid; palladium 10% on activated carbon; hydrogen; Dess-Martin periodane; triethylamine; In dichloromethane; ethyl acetate; acetone;

Reference yield:

: 392-09-6
2-fluoro-4-nitro-benzoic acid methyl ester

: 1402582-07-3
1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(3-fluoro-4-formylphenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate; methanol / 4 h / 23 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 6 h / 23 °C

3: pyridine / acetone / 1 h / 0 - 23 °C

4: triethylamine / dichloromethane / 16 h / 23 °C

5: Dess-Martin periodane / dichloromethane / 1.5 h / 0 °C

With pyridine; methanol; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; Dess-Martin periodane; triethylamine; In dichloromethane; ethyl acetate; acetone;