3-benzyl-3-methyl-5(E)-<3-(trimethylsilyl)prop-2-ynylidene>tetrahydro-2-furanone

Base Information

Chemical Name:3-benzyl-3-methyl-5(E)-<3-(trimethylsilyl)prop-2-ynylidene>tetrahydro-2-furanone
CAS No.:103437-80-5
Molecular Formula:C₁₈H₂₂O₂Si
Molecular Weight:298.457
Hs Code.:

Synonyms:3-benzyl-3-methyl-5(E)-<3-(trimethylsilyl)prop-2-ynylidene>tetrahydro-2-furanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-benzyl-3-methyl-5(E)-<3-(trimethylsilyl)prop-2-ynylidene>tetrahydro-2-furanone

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Technology Process of 3-benzyl-3-methyl-5(E)-<3-(trimethylsilyl)prop-2-ynylidene>tetrahydro-2-furanone

There total 5 articles about 3-benzyl-3-methyl-5(E)-<3-(trimethylsilyl)prop-2-ynylidene>tetrahydro-2-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 93040-55-2
3-benzyl-3-methyl-5(E)-(iodomethylene)tetrahydro-2-furanone

: 1066-54-2
trimethylsilylacetylene

: 103437-80-5
3-benzyl-3-methyl-5(E)-<3-(trimethylsilyl)prop-2-ynylidene>tetrahydro-2-furanone

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine;
DOI:10.1021/ja00278a038

Reference yield:

: 34666-01-8
ethyl 2-methyl-3-phenylpropionate

: 103437-80-5
3-benzyl-3-methyl-5(E)-<3-(trimethylsilyl)prop-2-ynylidene>tetrahydro-2-furanone

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / diisopropylamine, n-butyllithium / tetrahydrofuran / 1.75 h / 0 °C

2: 87 percent / 5 percent NaOH / ethanol / Heating

3: 80 percent / N-iodosuccinimide, NaHCO₃, tetrabutylammonium hydroxide / CH₂Cl₂; H₂O / 0.5 h

4: 66 percent / PdCl₂(Ph₃P)2, CuI, Et₃N

With bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; N-iodo-succinimide; copper(l) iodide; n-butyllithium; tetra(n-butyl)ammonium hydroxide; sodium hydrogencarbonate; triethylamine; diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/ja00278a038

Reference yield:

: 2021-28-5
ethyl dihydrocinnamate

: 103437-80-5
3-benzyl-3-methyl-5(E)-<3-(trimethylsilyl)prop-2-ynylidene>tetrahydro-2-furanone

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / diisopropylamine, n-butyllithium / tetrahydrofuran / 1.) -78 deg C, 1 h; 2.) room temperature 1 h

2: 67 percent / diisopropylamine, n-butyllithium / tetrahydrofuran / 1.75 h / 0 °C

3: 87 percent / 5 percent NaOH / ethanol / Heating

4: 80 percent / N-iodosuccinimide, NaHCO₃, tetrabutylammonium hydroxide / CH₂Cl₂; H₂O / 0.5 h

5: 66 percent / PdCl₂(Ph₃P)2, CuI, Et₃N

With bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; N-iodo-succinimide; copper(l) iodide; n-butyllithium; tetra(n-butyl)ammonium hydroxide; sodium hydrogencarbonate; triethylamine; diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/ja00278a038