6-ethyl 1-methyl 2-(4-methoxybenzyl)-3-(4-nitrophenyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate

Base Information

Chemical Name:6-ethyl 1-methyl 2-(4-methoxybenzyl)-3-(4-nitrophenyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate
CAS No.:1434004-12-2
Molecular Formula:C₂₈H₂₆N₄O₇
Molecular Weight:530.537
Hs Code.:

Synonyms:6-ethyl 1-methyl 2-(4-methoxybenzyl)-3-(4-nitrophenyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate

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Chemical Property of 6-ethyl 1-methyl 2-(4-methoxybenzyl)-3-(4-nitrophenyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate

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Technology Process of 6-ethyl 1-methyl 2-(4-methoxybenzyl)-3-(4-nitrophenyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate

There total 3 articles about 6-ethyl 1-methyl 2-(4-methoxybenzyl)-3-(4-nitrophenyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1434004-01-9
methyl 5-[2-azido-4-(ethoxycarbonyl)phenyl]-2-(4-methoxybenzyl)-3-(4-nitrophenyl)-2,3-dihydro-1H-pyrazole-1-carboxylate

: 1434004-12-2
6-ethyl 1-methyl 2-(4-methoxybenzyl)-3-(4-nitrophenyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate

Guidance literature:: With rhodium(III) chloride hydrate; In 1,2-dimethoxyethane; at 80 ℃; for 4h; Inert atmosphere;
DOI:10.1039/c3ob40223a

Reference yield:

: 1434003-91-4
ethyl 3-azido-4-ethynylbenzoate

: 1434004-12-2
6-ethyl 1-methyl 2-(4-methoxybenzyl)-3-(4-nitrophenyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: [AuCl(IPr)]; silver(I) triflimide / 1,2-dichloro-ethane / 50 °C / Inert atmosphere

2: rhodium(III) chloride hydrate / 1,2-dimethoxyethane / 4 h / 80 °C / Inert atmosphere

With rhodium(III) chloride hydrate; [AuCl(IPr)]; silver(I) triflimide; In 1,2-dimethoxyethane; 1,2-dichloro-ethane;
DOI:10.1039/c3ob40223a

Reference yield:

: 1260650-82-5
C₁₁H₁₁NO₂

: 1434004-12-2
6-ethyl 1-methyl 2-(4-methoxybenzyl)-3-(4-nitrophenyl)-1,2,3,4-tetrahydropyrazolo[4,3-b]indole-1,6-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium nitrite; sulfuric acid / water; acetonitrile; N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 0.5 h / 0 - 20 °C

2.1: [AuCl(IPr)]; silver(I) triflimide / 1,2-dichloro-ethane / 50 °C / Inert atmosphere

3.1: rhodium(III) chloride hydrate / 1,2-dimethoxyethane / 4 h / 80 °C / Inert atmosphere

With rhodium(III) chloride hydrate; sulfuric acid; [AuCl(IPr)]; silver(I) triflimide; sodium nitrite; In 1,2-dimethoxyethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3ob40223a