N-{2,4-difluoro-3-[2-(4-methylpiperazin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]phenyl}-2,5-difluorobenzenesulfonamide

Base Information

Chemical Name:N-{2,4-difluoro-3-[2-(4-methylpiperazin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]phenyl}-2,5-difluorobenzenesulfonamide
CAS No.:1394938-78-3
Molecular Formula:C₂₅H₂₁F₄N₅O₂S₂
Molecular Weight:563.6
Hs Code.:

Synonyms:N-{2,4-difluoro-3-[2-(4-methylpiperazin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]phenyl}-2,5-difluorobenzenesulfonamide

Suppliers and Price of N-{2,4-difluoro-3-[2-(4-methylpiperazin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]phenyl}-2,5-difluorobenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-{2,4-difluoro-3-[2-(4-methylpiperazin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]phenyl}-2,5-difluorobenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-{2,4-difluoro-3-[2-(4-methylpiperazin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]phenyl}-2,5-difluorobenzenesulfonamide

There total 4 articles about N-{2,4-difluoro-3-[2-(4-methylpiperazin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]phenyl}-2,5-difluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1394938-86-3
N-{3-[5-bromo-2-(4-methyl-piperazin-1-yl)-thiazol-4-yl]-2,4-difluoro-phenyl}-2,5-difluoro-benzenesulfonamide

: 181219-01-2
4-pyridineboronic acid pinacol ester

: 1394938-78-3
N-{2,4-difluoro-3-[2-(4-methylpiperazin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]phenyl}-2,5-difluorobenzenesulfonamide

Guidance literature:: N-{3-[5-bromo-2-(4-methyl-piperazin-1-yl)-thiazol-4-yl]-2,4-difluoro-phenyl}-2,5-difluoro-benzenesulfonamide; 4-pyridineboronic acid pinacol ester; With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; at 110 ℃; for 1h; Microwave irradiation;

With ammonium hydroxide; In dichloromethane; water;

Reference yield:

: 1206836-18-1
N-(3-acetyl-2,4-difluoro-phenyl)-2,5-difluoro-benzenesulfonamide

: 1394938-78-3
N-{2,4-difluoro-3-[2-(4-methylpiperazin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]phenyl}-2,5-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: bromine; hydrogen bromide; acetic acid / water / 21 h / 20 °C

2: ethanol / 0.33 h / 60 °C / Microwave irradiation

3: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

4: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 1 h / 110 °C / Microwave irradiation

With N-Bromosuccinimide; hydrogen bromide; bromine; caesium carbonate; acetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 4: Suzuki Coupling;

Reference yield:

: 1394938-80-7
N-[3-(2-bromo-acetyl)-2,4-difluoro-phenyl]-2,5-difluoro-benzenesulfonamide

: 1394938-78-3
N-{2,4-difluoro-3-[2-(4-methylpiperazin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]phenyl}-2,5-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 0.33 h / 60 °C / Microwave irradiation

2: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 1 h / 110 °C / Microwave irradiation

With N-Bromosuccinimide; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 3: Suzuki Coupling;