N-(3-((5-(isoquinolin-6-yl)oxazol-2-yl)amino)phenyl)methanesulfonamide

Base Information

Chemical Name:N-(3-((5-(isoquinolin-6-yl)oxazol-2-yl)amino)phenyl)methanesulfonamide
CAS No.:1415114-24-7
Molecular Formula:C₁₉H₁₆N₄O₃S
Molecular Weight:380.427
Hs Code.:

Synonyms:N-(3-((5-(isoquinolin-6-yl)oxazol-2-yl)amino)phenyl)methanesulfonamide

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Chemical Property of N-(3-((5-(isoquinolin-6-yl)oxazol-2-yl)amino)phenyl)methanesulfonamide

Chemical Property:

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Technology Process of N-(3-((5-(isoquinolin-6-yl)oxazol-2-yl)amino)phenyl)methanesulfonamide

There total 7 articles about N-(3-((5-(isoquinolin-6-yl)oxazol-2-yl)amino)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1415114-76-9
2-chloro-5-(isoquinolin-6-yl)oxazole

: 37045-73-1
3-(methylsulfonamido)aniline

: 1415114-24-7
N-(3-((5-(isoquinolin-6-yl)oxazol-2-yl)amino)phenyl)methanesulfonamide

Guidance literature:: In isopropyl alcohol; at 80 ℃; for 24h;

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 1415114-24-7
N-(3-((5-(isoquinolin-6-yl)oxazol-2-yl)amino)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / methanol / 1.5 h / Reflux

2.1: hydrogen / palladium on activated charcoal / methanol / 14 h

3.1: pyridine / 6 h / 20 °C

4.1: potassium carbonate / 18-crown-6 ether / N,N-dimethyl-formamide / 12 h / 120 °C

5.1: aluminum (III) chloride / dichloromethane / 20 °C

5.2: Cooling with ice

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

6.2: 16 h / -78 - 20 °C

7.1: isopropyl alcohol / 24 h / 80 °C

With pyridine; aluminum (III) chloride; hydrogen; potassium carbonate; lithium hexamethyldisilazane; 18-crown-6 ether; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 672324-91-3
[4-(1,3-oxazol-5-yl)phenyl]methanamine

: 1415114-24-7
N-(3-((5-(isoquinolin-6-yl)oxazol-2-yl)amino)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 6 h / 20 °C

2.1: potassium carbonate / 18-crown-6 ether / N,N-dimethyl-formamide / 12 h / 120 °C

3.1: aluminum (III) chloride / dichloromethane / 20 °C

3.2: Cooling with ice

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

4.2: 16 h / -78 - 20 °C

5.1: isopropyl alcohol / 24 h / 80 °C

With pyridine; aluminum (III) chloride; potassium carbonate; lithium hexamethyldisilazane; 18-crown-6 ether; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;