methyl 2-(4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)bicyclo[2.2.2]octan-1-yl)acetate

Base Information

Chemical Name:methyl 2-(4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)bicyclo[2.2.2]octan-1-yl)acetate
CAS No.:1166828-23-4
Molecular Formula:C₂₄H₂₉N₃O₃
Molecular Weight:407.513
Hs Code.:

Synonyms:methyl 2-(4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)bicyclo[2.2.2]octan-1-yl)acetate

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Chemical Property of methyl 2-(4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)bicyclo[2.2.2]octan-1-yl)acetate

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Technology Process of methyl 2-(4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)bicyclo[2.2.2]octan-1-yl)acetate

There total 5 articles about methyl 2-(4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)bicyclo[2.2.2]octan-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1166828-19-8
6-chloro-3,5-dimethylpyrazine-2-carboxamide

: 1166828-25-6
methyl 2-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)bicyclo[2.2.2]octan-1-yl)acetate

: 1166828-23-4
methyl 2-(4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)bicyclo[2.2.2]octan-1-yl)acetate

Guidance literature:: With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; ethanol; water; at 80 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm301296t

Reference yield: 96.0%

: 1166828-23-4
methyl 2-(4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)bicyclo[2.2.2]octan-1-yl)acetate

Guidance literature:

Reference yield:

: 1166828-27-8
methyl 2-(4-(4-iodophenyl)bicyclo[2.2.2]octan-1-yl)acetate

: 1166828-23-4
methyl 2-(4-(4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl)bicyclo[2.2.2]octan-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 3 h / 80 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / water; 1,2-dimethoxyethane; ethanol / 1 h / 80 °C / Inert atmosphere

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide;
DOI:10.1021/jm301296t