2-Dibromomethyl-benzoic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yl ester; compound with triethyl-amine

Base Information

• Chemical Name: 2-Dibromomethyl-benzoic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yl ester; compound with triethyl-amine
• CAS No.: 77244-74-7
• Molecular Formula: C₆H₁₅N*C₅₀H₃₇Br₂ClN₅O₁₀P
• Molecular Weight: 1195.3
• Mol file: 77244-74-7.mol

Synonyms:2-Dibromomethyl-benzoic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yl ester; compound with triethyl-amine

Chemical Property of 2-Dibromomethyl-benzoic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yl ester; compound with triethyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Dibromomethyl-benzoic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yl ester; compound with triethyl-amine

There total 6 articles about 2-Dibromomethyl-benzoic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yl ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

o-di-bromomethyl-benzoyl chloride (73407-51-9) → 2-Dibromomethyl-benzoic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yl ester; compound with triethyl-amine (77244-74-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / triethylamine / methanol / Ambient temperature

2: 79 percent / 4 Angstroem molecular sieves / dimethylformamide; CHCl₃ / Ambient temperature

3: triethylamine, 4 Angstroem molecular sieves / acetonitrile / 0.42 h / 20 °C

4: triethylamine, water / 0.17 h

With 4 A molecular sieve; water; triethylamine; In methanol; chloroform; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/0040-4039(80)88081-6

Reference yield:

2',3'-O-(dibutylstannylene)-N6-benzoyladenosine (77244-79-2) → 2-Dibromomethyl-benzoic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yl ester; compound with triethyl-amine (77244-74-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / triethylamine / methanol / Ambient temperature

2: 79 percent / 4 Angstroem molecular sieves / dimethylformamide; CHCl₃ / Ambient temperature

3: triethylamine, 4 Angstroem molecular sieves / acetonitrile / 0.42 h / 20 °C

4: triethylamine, water / 0.17 h

With 4 A molecular sieve; water; triethylamine; In methanol; chloroform; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/0040-4039(80)88081-6

Reference yield:

3'-O-2-dibromomethylbenzoyl-6-N-benzoyl adenosine (77244-69-0) → 2-Dibromomethyl-benzoic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yl ester; compound with triethyl-amine (77244-74-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / 4 Angstroem molecular sieves / dimethylformamide; CHCl₃ / Ambient temperature

2: triethylamine, 4 Angstroem molecular sieves / acetonitrile / 0.42 h / 20 °C

3: triethylamine, water / 0.17 h

With 4 A molecular sieve; water; triethylamine; In chloroform; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/0040-4039(80)88081-6

upstream raw materials:

2-Dibromomethyl-benzoic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-[(2-chloro-phenoxy)-[1,2,4]triazol-1-yl-phosphinoyloxy]-2-(9-phenyl-9H-xanthen-9-yloxymethyl)-tetrahydro-furan-3-yl ester

o-di-bromomethyl-benzoyl chloride

2',3'-O-(dibutylstannylene)-N⁶-benzoyladenosine

3'-O-2-dibromomethylbenzoyl-6-N-benzoyl adenosine

Downstream raw materials:

C₈₁H₆₀Br₂ClN₁₀O₁₆P

C₁₁₉H₈₇Br₄Cl₂N₁₅O₂₅P₂