(E)-3-(4-bromo-3'-(4-(1,3-dioxoisoindolin-2-yl)butyl)[1,1'-biphenyl]-2-yl)acrylamide

Base Information

Chemical Name:(E)-3-(4-bromo-3'-(4-(1,3-dioxoisoindolin-2-yl)butyl)[1,1'-biphenyl]-2-yl)acrylamide
CAS No.:1426943-42-1
Molecular Formula:C₂₇H₂₃BrN₂O₃
Molecular Weight:503.395
Hs Code.:

Synonyms:(E)-3-(4-bromo-3'-(4-(1,3-dioxoisoindolin-2-yl)butyl)[1,1'-biphenyl]-2-yl)acrylamide

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Chemical Property of (E)-3-(4-bromo-3'-(4-(1,3-dioxoisoindolin-2-yl)butyl)[1,1'-biphenyl]-2-yl)acrylamide

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Technology Process of (E)-3-(4-bromo-3'-(4-(1,3-dioxoisoindolin-2-yl)butyl)[1,1'-biphenyl]-2-yl)acrylamide

There total 6 articles about (E)-3-(4-bromo-3'-(4-(1,3-dioxoisoindolin-2-yl)butyl)[1,1'-biphenyl]-2-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: potassium (3-(4-(1,3-dioxoisoindolin-2-yl)butyl)phenyl)trifluoroborate

: (E)-2-(3-amino-3-oxoprop-1-en-1-yl)-4-bromobenzenediazonium tetrafluoroborate

: 1426943-42-1
(E)-3-(4-bromo-3'-(4-(1,3-dioxoisoindolin-2-yl)butyl)[1,1'-biphenyl]-2-yl)acrylamide

Guidance literature:: With palladium diacetate; In methanol; at -20 - 0 ℃; Inert atmosphere; Schlenk technique;
DOI:10.1002/chem.201203005

Reference yield:

: 1426943-07-8
2-(4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butyl)isoindoline-1,3-dione

: 1426943-42-1
(E)-3-(4-bromo-3'-(4-(1,3-dioxoisoindolin-2-yl)butyl)[1,1'-biphenyl]-2-yl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; potassium hydrogen bifluoride / methanol / 16 h / 20 °C

2: palladium diacetate / methanol / -20 - 0 °C / Inert atmosphere; Schlenk technique

With potassium hydrogen bifluoride; water; palladium diacetate; In methanol; 2: |Suzuki Coupling;
DOI:10.1002/chem.201203005

Reference yield:

: 1426942-96-2
(E)-3-(5-bromo-2-nitrophenyl)acrylamide

: 1426943-42-1
(E)-3-(4-bromo-3'-(4-(1,3-dioxoisoindolin-2-yl)butyl)[1,1'-biphenyl]-2-yl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: tin; acetic acid / 48 h / 20 °C / Inert atmosphere; Darkness

2: boron trifluoride diethyl etherate; tert.-butylnitrite / tetrahydrofuran / -45 - -5 °C / Inert atmosphere

3: palladium diacetate / methanol / -20 - 0 °C / Inert atmosphere; Schlenk technique

With tin; tert.-butylnitrite; boron trifluoride diethyl etherate; palladium diacetate; acetic acid; In tetrahydrofuran; methanol; 3: |Suzuki Coupling;
DOI:10.1002/chem.201203005