methyl (2S)-2-[{[5-bromo-2-(4-morpholino)-1,3-thiazol-4-yl]methyl}(phenylsulfonyl)amino] propanoate

Base Information

Chemical Name:methyl (2S)-2-[{[5-bromo-2-(4-morpholino)-1,3-thiazol-4-yl]methyl}(phenylsulfonyl)amino] propanoate
CAS No.:436844-30-3
Molecular Formula:C₁₈H₂₂BrN₃O₅S₂
Molecular Weight:504.426
Hs Code.:

Synonyms:methyl (2S)-2-[{[5-bromo-2-(4-morpholino)-1,3-thiazol-4-yl]methyl}(phenylsulfonyl)amino] propanoate

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Chemical Property of methyl (2S)-2-[{[5-bromo-2-(4-morpholino)-1,3-thiazol-4-yl]methyl}(phenylsulfonyl)amino] propanoate

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Technology Process of methyl (2S)-2-[{[5-bromo-2-(4-morpholino)-1,3-thiazol-4-yl]methyl}(phenylsulfonyl)amino] propanoate

There total 1 articles about methyl (2S)-2-[{[5-bromo-2-(4-morpholino)-1,3-thiazol-4-yl]methyl}(phenylsulfonyl)amino] propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 59724-68-4
N-phenylsulfonyl-L-alanine methyl ester

: 4-(5-bromo-4-bromomethyl-thiazol-2-yl)-morpholine

: 436844-30-3
methyl (2S)-2-[{[5-bromo-2-(4-morpholino)-1,3-thiazol-4-yl]methyl}(phenylsulfonyl)amino] propanoate

Guidance literature:: With potassium carbonate; In acetonitrile; for 2h; Heating;
DOI:10.1021/jo010665z

Reference yield: 86.0%

: 436844-30-3
methyl (2S)-2-[{[5-bromo-2-(4-morpholino)-1,3-thiazol-4-yl]methyl}(phenylsulfonyl)amino] propanoate

: 436844-31-4
(6S)-6-methyl-2-(4-morpholino)-5-phenylsulfonyl-5,6-dihydro[1,3]thiazolo[4,5-c]pyridin-7(4H)-one

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -100 ℃;
DOI:10.1021/jo010665z

Reference yield:

: 436844-30-3
methyl (2S)-2-[{[5-bromo-2-(4-morpholino)-1,3-thiazol-4-yl]methyl}(phenylsulfonyl)amino] propanoate

: (3aS,6S,7R,7aS)-7-methoxy-3,6-dimethyl-5-(phenylsulfonyl)octahydro[1,3]thiazolo[4,5-c]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / n-BuLi / hexane; tetrahydrofuran / -100 °C

2: 94 percent / NaBH₄ / tetrahydrofuran; ethanol / 2 h / 20 °C

3: 100 percent / BaO₂; Ba(OH)2*8H₂O / dimethylsulfoxide; dimethylformamide / 18 h / 20 °C

4: 71 percent / CH₂Cl₂ / 0 °C

5: 44 percent / NaBH₄ / methanol / 0.17 h / 20 °C

With barium dihydroxide; sodium tetrahydroborate; n-butyllithium; barium peroxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo010665z