2-ADAMANTANE ISOTHIOCYANATE

Base Information

• Chemical Name: 2-ADAMANTANE ISOTHIOCYANATE
• CAS No.: 65068-86-2
• Molecular Formula: C₁₁H₁₅NS
• Molecular Weight: 193.313
• Mol file: 65068-86-2.mol

Synonyms:2-isothiocyanatoadamantane

Chemical Property of 2-ADAMANTANE ISOTHIOCYANATE

Chemical Property:

• Melting Point: 147-150°C

Purity/Quality:

2-isothiocyanatoadamantane 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-ADAMANTANE ISOTHIOCYANATE

There total 9 articles about 2-ADAMANTANE ISOTHIOCYANATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-adamatylcarbamodithioic acid → 2-isothiocyanatoadamantane (65068-86-2)

Guidance literature:

With dmap; di-tert-butyl dicarbonate; In ethanol; at 0 - 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.0c01971

Reference yield:

C11H17NS2*C6H15N → 2-isothiocyanatoadamantane (65068-86-2)

Guidance literature:

With dmap; di-tert-butyl dicarbonate; In ethanol; at 0 - 20 ℃;

DOI:10.1134/S1070428018100068

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + N-(2-adamantyl)amine (13074-39-0) → 2-isothiocyanatoadamantane (65068-86-2)

Guidance literature:

With dicyclohexyl-carbodiimide; In diethyl ether;

upstream raw materials:

carbon disulfide

N-(2-adamantyl)amine

2-Adamantanone

N-(adamantan-2-yl)formamide

Downstream raw materials:

2-(Phenylthio)-tricyclo<3.3.1.1³,7>dec-2-ylisothiocyanat

1.1-Dibenzyl-3-(tricyclo<3.3.1.1^3.7>dec-2-yliden)thioharnstoff

1,1-Dibenzyl-3-(tricyclo<3.3.1.1^3.7>dec-2-yl)thioharnstoff

(3-Isatin)-4-(2-adamantyl)thiosemicarbazon

Refernces

• 1、 Kovaleva, Kseniya,Yarovaya, Olga,Ponomarev, Konstantin,Cheresiz, Sergey,Azimirad, Amirhossein,Chernyshova, Irina,Zakharenko, Alexandra,Konev, Vasily,Khlebnikova, Tatiana,Mozhaytsev, Evgenii,Suslov, Evgenii,Nilov, Dmitry,?vedas, Vytas,Pokrovsky, Andrey,Lavrik, Olga,Salakhutdinov, Nariman. "Design, synthesis, and molecular docking study of new tyrosyl-dna phosphodiesterase 1 (Tdp1) inhibitors combining resin acids and adamantane moieties". . . Retrieved 2021/05/22.
• 2、 Kreutzberger,Schroders,Stratmann. "Antiviral agents, XXIV: 4-(2-Adamantyl)thiosemicarbazones". . p. 767 - 771. Retrieved 2007/10/02.