6-((2,2,2-Trifluoroethoxy)methyl)nicotinic acid

Base Information

Chemical Name:6-((2,2,2-Trifluoroethoxy)methyl)nicotinic acid
CAS No.:1072855-75-4
Molecular Formula:C₉H₈F₃NO₃
Molecular Weight:235.163
Hs Code.:
DSSTox Substance ID:DTXSID50697388
Wikidata:Q72511084
Mol file:1072855-75-4.mol

Synonyms:6-((2,2,2-Trifluoroethoxy)methyl)nicotinic acid;1072855-75-4;6-(2,2,2-trifluoroethoxymethyl)pyridine-3-carboxylic acid;6-[(2,2,2-TRIFLUOROETHOXY)METHYL]NICOTINIC ACID;SCHEMBL841768;DTXSID50697388;6-[(2,2,2-Trifluoroethoxy)methyl]pyridine-3-carboxylic acid;AKOS016006489;CS-0367212;6-((2,2,2-Trifluoroethoxy)methyl)nicotinicacid

Suppliers and Price of 6-((2,2,2-Trifluoroethoxy)methyl)nicotinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
6-((2,2,2-Trifluoroethoxy)methyl)nicotinicacid 95+%
1g
$ 535.00

Chemenu
6-((2,2,2-Trifluoroethoxy)methyl)nicotinicacid 95%
1g
$ 505.00

American Custom Chemicals Corporation
6-((2,2,2-TRIFLUOROETHOXY)METHYL)NICOTINIC ACID 95.00%
5MG
$ 504.03

Alichem
6-((2,2,2-Trifluoroethoxy)methyl)nicotinicacid
1g
$ 431.64

Total 13 raw suppliers

Chemical Property of 6-((2,2,2-Trifluoroethoxy)methyl)nicotinic acid

Chemical Property:

Storage Temp.:2-8°C
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:235.04562760
Heavy Atom Count:16
Complexity:245

Purity/Quality:

97% ^*data from raw suppliers

6-((2,2,2-Trifluoroethoxy)methyl)nicotinicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=NC=C1C(=O)O)COCC(F)(F)F

Technology Process of 6-((2,2,2-Trifluoroethoxy)methyl)nicotinic acid

There total 1 articles about 6-((2,2,2-Trifluoroethoxy)methyl)nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56026-36-9
methyl 6-(hydroxymethyl)nicotinate

: 1072855-75-4
6-((2,2,2-trifluoroethoxy)methyl)nicotinic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; triethylamine / dichloromethane / 1 h / -78 °C / Inert atmosphere

2.1: potassium hydroxide / Aliquat 336 / dichloromethane / 0.25 h / 30 °C / Inert atmosphere

2.2: 0.25 h

With dmap; triethylamine; potassium hydroxide; Aliquat 336; In dichloromethane;

Reference yield: 66.1%

: 1072855-75-4
6-((2,2,2-trifluoroethoxy)methyl)nicotinic acid

: 1404115-30-5
2,2-difluoro-2-(2-(5-methoxypyrazin-2-yl)phenyl)ethanamine

: 1404115-21-4
C₂₂H₁₉F₅N₄O₃

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In acetonitrile; at 20 ℃;
DOI:10.1016/j.bmcl.2012.08.031

Reference yield: 38.6%

: 1072855-75-4
6-((2,2,2-trifluoroethoxy)methyl)nicotinic acid

: 1404115-26-9
2-(3,6-difluoro-2-(5-methylpyrazin-2-yl)phenyl)ethanamine

: 1404115-12-3
C₂₂H₁₉F₅N₄O₂

Guidance literature:: 6-((2,2,2-trifluoroethoxy)methyl)nicotinic acid; With 1,1'-carbonyldiimidazole; In ethyl acetate; at 60 ℃; for 0.416667h; Inert atmosphere;

2-(3,6-difluoro-2-(5-methylpyrazin-2-yl)phenyl)ethanamine; In ethyl acetate; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.08.031