(R)-1-<2-hydroxy-1-(2-methoxy-6-methylphenyl)ethyl>-1H-pyrrole-2,5-dione

Base Information

Chemical Name:(R)-1-<2-hydroxy-1-(2-methoxy-6-methylphenyl)ethyl>-1H-pyrrole-2,5-dione
CAS No.:151858-82-1
Molecular Formula:C₁₄H₁₅NO₄
Molecular Weight:261.277
Hs Code.:

Synonyms:(R)-1-<2-hydroxy-1-(2-methoxy-6-methylphenyl)ethyl>-1H-pyrrole-2,5-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-<2-hydroxy-1-(2-methoxy-6-methylphenyl)ethyl>-1H-pyrrole-2,5-dione

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Technology Process of (R)-1-<2-hydroxy-1-(2-methoxy-6-methylphenyl)ethyl>-1H-pyrrole-2,5-dione

There total 9 articles about (R)-1-<2-hydroxy-1-(2-methoxy-6-methylphenyl)ethyl>-1H-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 151858-79-6
(R)-1-<2-(acetyloxy)-1-(2-methoxy-6-methylphenyl)ethyl>-1H-pyrrole-2,5-dione

: 151858-82-1
(R)-1-<2-hydroxy-1-(2-methoxy-6-methylphenyl)ethyl>-1H-pyrrole-2,5-dione

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 36h; Ambient temperature;
DOI:10.1021/ja00076a036

Reference yield:

: 151858-72-9
(4S,5R)-3-(2-(2-methoxy-6-methylphenyl)acetyl)-4-methyl-5-phenyl-1,3-oxazolidin-2-one

: 151858-82-1
(R)-1-<2-hydroxy-1-(2-methoxy-6-methylphenyl)ethyl>-1H-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) KN(SiMe₃)2, 2.) trisyl azide, 3.) AcOH

2: 83 percent / NaBH₄ / tetrahydrofuran; H₂O / 42 h / 5 °C

3: 78 percent / H₂ / 10percent Pd/C / ethanol / 24 h / Ambient temperature

4: 80 percent / diethyl ether / 20 h / Ambient temperature

5: 44 percent / 20 h / 120 °C

6: 76 percent / 5N HCl / tetrahydrofuran / 36 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; potassium hexamethylsilazane; acetic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; water;
DOI:10.1021/ja00076a036

Reference yield:

: C₁₅H₂₀O₄

: 151858-82-1
(R)-1-<2-hydroxy-1-(2-methoxy-6-methylphenyl)ethyl>-1H-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, a) -78 deg C, 15 min, b) RT, 9 h

2: 1.) KN(SiMe₃)2, 2.) trisyl azide, 3.) AcOH

3: 83 percent / NaBH₄ / tetrahydrofuran; H₂O / 42 h / 5 °C

4: 78 percent / H₂ / 10percent Pd/C / ethanol / 24 h / Ambient temperature

5: 80 percent / diethyl ether / 20 h / Ambient temperature

6: 44 percent / 20 h / 120 °C

7: 76 percent / 5N HCl / tetrahydrofuran / 36 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; potassium hexamethylsilazane; acetic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; water;
DOI:10.1021/ja00076a036