ethyl 3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazole-4-carboxylate

Base Information

Chemical Name:ethyl 3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazole-4-carboxylate
CAS No.:79291-60-4
Molecular Formula:C₁₄H₁₅F₃N₄O₂
Molecular Weight:328.294
Hs Code.:

Synonyms:ethyl 3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazole-4-carboxylate

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Chemical Property of ethyl 3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazole-4-carboxylate

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Technology Process of ethyl 3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazole-4-carboxylate

There total 3 articles about ethyl 3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 79291-41-1
ethyl 1-methyl-3-(2-nitro-4-trifluoromethylanilino)pyrazole-4-carboxylate

: 79291-60-4
ethyl 3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazole-4-carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; under 3102.9 Torr;
DOI:10.1021/jm00132a012

Reference yield:

: 21230-43-3
3-amino-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

: 79291-60-4
ethyl 3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) n-BuLi / 1) THF, hexane, -15 deg C, 10 min, 2) THF, r.t., 1 h

2: 90 percent / H₂ / Pd/C(10percent) / ethyl acetate; ethanol / 3102.9 Torr

With n-butyllithium; hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1021/jm00132a012

Reference yield:

: 367-86-2
1-fluoro-2-nitro-4-trifluoromethyl-benzene

: 79291-60-4
ethyl 3-<<2-amino-4-(trifluoromethyl)phenyl>amino>-1-methylpyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) n-BuLi / 1) THF, hexane, -15 deg C, 10 min, 2) THF, r.t., 1 h

2: 90 percent / H₂ / Pd/C(10percent) / ethyl acetate; ethanol / 3102.9 Torr

With n-butyllithium; hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1021/jm00132a012