5-(4-chlorophenyl)-2-{[1-(2-chlorophenyl)-1H-imidazol-4-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Base Information

Chemical Name:5-(4-chlorophenyl)-2-{[1-(2-chlorophenyl)-1H-imidazol-4-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one
CAS No.:1332502-31-4
Molecular Formula:C₂₁H₁₆Cl₂F₃N₅O₂
Molecular Weight:498.292
Hs Code.:

Synonyms:5-(4-chlorophenyl)-2-{[1-(2-chlorophenyl)-1H-imidazol-4-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

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Chemical Property of 5-(4-chlorophenyl)-2-{[1-(2-chlorophenyl)-1H-imidazol-4-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

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Technology Process of 5-(4-chlorophenyl)-2-{[1-(2-chlorophenyl)-1H-imidazol-4-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

There total 8 articles about 5-(4-chlorophenyl)-2-{[1-(2-chlorophenyl)-1H-imidazol-4-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1245623-49-7
5-(4-chlorophenyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

: 1332502-99-4
4-(bromomethyl)-1-(2-chlorophenyl)-1H-imidazole

: 1332502-31-4
5-(4-chlorophenyl)-2-{[1-(2-chlorophenyl)-1H-imidazol-4-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 - 65 ℃; for 22h;

Reference yield:

: 3900-89-8
2-Chlorobenzeneboronic acid

: 1332502-31-4
5-(4-chlorophenyl)-2-{[1-(2-chlorophenyl)-1H-imidazol-4-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: copper diacetate; pyridine / dichloromethane / 20 h / 20 °C / Molecular sieve

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -10 - 20 °C

3: triphenylphosphine; carbon tetrabromide / tetrahydrofuran / 16 h / 20 °C

4: potassium carbonate / acetonitrile / 22 h / 20 - 65 °C

With pyridine; lithium aluminium tetrahydride; carbon tetrabromide; copper diacetate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 1332502-92-7
methyl 1-(2-chlorophenyl)-1H-imidazole-4-carboxylate

: 1332502-31-4
5-(4-chlorophenyl)-2-{[1-(2-chlorophenyl)-1H-imidazol-4-yl]methyl}-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -10 - 20 °C

2: triphenylphosphine; carbon tetrabromide / tetrahydrofuran / 16 h / 20 °C

3: potassium carbonate / acetonitrile / 22 h / 20 - 65 °C

With lithium aluminium tetrahydride; carbon tetrabromide; potassium carbonate; triphenylphosphine; In tetrahydrofuran; acetonitrile;