(2S,4S,6S)-6-((R)-2-((tert-butyldiphenylsilyl)oxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyl-2-(2-oxo-4-((trimethylsilyl)methyl)pent-4-en-1-yl)tetrahydro-2H-pyran-4-yl acetate

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Chemical Name:(2S,4S,6S)-6-((R)-2-((tert-butyldiphenylsilyl)oxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyl-2-(2-oxo-4-((trimethylsilyl)methyl)pent-4-en-1-yl)tetrahydro-2H-pyran-4-yl acetate
CAS No.:1261423-37-3
Molecular Formula:C₄₃H₆₆O₇SSi₂
Molecular Weight:783.23
Hs Code.:

(2S,4S,6S)-6-((R)-2-((tert-butyldiphenylsilyl)oxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyl-2-(2-oxo-4-((trimethylsilyl)methyl)pent-4-en-1-yl)tetrahydro-2H-pyran-4-yl acetate

Synonyms:(2S,4S,6S)-6-((R)-2-((tert-butyldiphenylsilyl)oxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyl-2-(2-oxo-4-((trimethylsilyl)methyl)pent-4-en-1-yl)tetrahydro-2H-pyran-4-yl acetate

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Chemical Property of (2S,4S,6S)-6-((R)-2-((tert-butyldiphenylsilyl)oxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyl-2-(2-oxo-4-((trimethylsilyl)methyl)pent-4-en-1-yl)tetrahydro-2H-pyran-4-yl acetate

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Technology Process of (2S,4S,6S)-6-((R)-2-((tert-butyldiphenylsilyl)oxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyl-2-(2-oxo-4-((trimethylsilyl)methyl)pent-4-en-1-yl)tetrahydro-2H-pyran-4-yl acetate

There total 3 articles about (2S,4S,6S)-6-((R)-2-((tert-butyldiphenylsilyl)oxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyl-2-(2-oxo-4-((trimethylsilyl)methyl)pent-4-en-1-yl)tetrahydro-2H-pyran-4-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1261423-35-1
(2S,4S,6S)-6-((R)-2-((tert-butyldiphenylsilyl)oxy)-4-(tert-butylthio)-4-oxobutyl)-2-(2-hydroxy-4-((trimethylsilyl)methyl)pent-4-en-1-yl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-4-yl acetate

: 1261423-37-3
(2S,4S,6S)-6-((R)-2-((tert-butyldiphenylsilyl)oxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyl-2-(2-oxo-4-((trimethylsilyl)methyl)pent-4-en-1-yl)tetrahydro-2H-pyran-4-yl acetate

Guidance literature:: (2S,4S,6S)-6-((R)-2-((tert-butyldiphenylsilyl)oxy)-4-(tert-butylthio)-4-oxobutyl)-2-(2-hydroxy-4-((trimethylsilyl)methyl)pent-4-en-1-yl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-4-yl acetate; With dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -15 ℃; for 0.166667h;

With sulfur trioxide pyridine complex; In dichloromethane; at -15 ℃; for 1h;
DOI:10.1021/ja110198y

Reference yield:

: 916991-63-4
C₃₆H₅₂O₇SSi

: 1261423-37-3
(2S,4S,6S)-6-((R)-2-((tert-butyldiphenylsilyl)oxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyl-2-(2-oxo-4-((trimethylsilyl)methyl)pent-4-en-1-yl)tetrahydro-2H-pyran-4-yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 12 h / Reflux

2.1: dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / -15 °C

2.2: 1 h / -15 °C

With dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;
DOI:10.1021/ja110198y

Reference yield:

: 164662-96-8
1-trimethylsilyl-2-(tributylstannyl)methyl-2-propene

: 1261423-37-3
(2S,4S,6S)-6-((R)-2-((tert-butyldiphenylsilyl)oxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyl-2-(2-oxo-4-((trimethylsilyl)methyl)pent-4-en-1-yl)tetrahydro-2H-pyran-4-yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 12 h / Reflux

2.1: dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / -15 °C

2.2: 1 h / -15 °C

With dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;
DOI:10.1021/ja110198y